Cargando…
Exacerbations of chronic respiratory diseases
Respiratory viral infections including human rhinovirus (RV) infection have been identified as the most important environmental trigger of exacerbations of chronic lung diseases. While well established as the most common viral infections associated with exacerbations of asthma and chronic obstructiv...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173443/ http://dx.doi.org/10.1016/B978-0-12-816417-4.00006-8 |
_version_ | 1783524452708909056 |
---|---|
author | Edwards, Michael R. Ritchie, Andrew I. Johnston, Sebastian L. |
author_facet | Edwards, Michael R. Ritchie, Andrew I. Johnston, Sebastian L. |
author_sort | Edwards, Michael R. |
collection | PubMed |
description | Respiratory viral infections including human rhinovirus (RV) infection have been identified as the most important environmental trigger of exacerbations of chronic lung diseases. While well established as the most common viral infections associated with exacerbations of asthma and chronic obstructive pulmonary disease, RVs and other respiratory viruses are also now thought to be important in triggering exacerbations of cystic fibrosis and the interstitial lung diseases. Here, we summarize the epidemiological evidence the supports respiratory viruses including RV as triggers of exacerbations of chronic lung diseases. We propose that certain characteristics of RVs may explain why they are the most common trigger of exacerbations of chronic lung diseases. We further highlight the latest mechanistic evidence supporting how and why common respiratory viral infections may enhance and promote disease triggering exacerbation events, through their interactions with the host immune system, and may be affected by ongoing treatments. We also provide a commentary on how new treatments may better manage the disease burden associated with respiratory viral infections and the exacerbation events that they trigger. |
format | Online Article Text |
id | pubmed-7173443 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
record_format | MEDLINE/PubMed |
spelling | pubmed-71734432020-04-22 Exacerbations of chronic respiratory diseases Edwards, Michael R. Ritchie, Andrew I. Johnston, Sebastian L. Rhinovirus Infections Article Respiratory viral infections including human rhinovirus (RV) infection have been identified as the most important environmental trigger of exacerbations of chronic lung diseases. While well established as the most common viral infections associated with exacerbations of asthma and chronic obstructive pulmonary disease, RVs and other respiratory viruses are also now thought to be important in triggering exacerbations of cystic fibrosis and the interstitial lung diseases. Here, we summarize the epidemiological evidence the supports respiratory viruses including RV as triggers of exacerbations of chronic lung diseases. We propose that certain characteristics of RVs may explain why they are the most common trigger of exacerbations of chronic lung diseases. We further highlight the latest mechanistic evidence supporting how and why common respiratory viral infections may enhance and promote disease triggering exacerbation events, through their interactions with the host immune system, and may be affected by ongoing treatments. We also provide a commentary on how new treatments may better manage the disease burden associated with respiratory viral infections and the exacerbation events that they trigger. 2019 2019-07-11 /pmc/articles/PMC7173443/ http://dx.doi.org/10.1016/B978-0-12-816417-4.00006-8 Text en Copyright © 2019 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Edwards, Michael R. Ritchie, Andrew I. Johnston, Sebastian L. Exacerbations of chronic respiratory diseases |
title | Exacerbations of chronic respiratory diseases |
title_full | Exacerbations of chronic respiratory diseases |
title_fullStr | Exacerbations of chronic respiratory diseases |
title_full_unstemmed | Exacerbations of chronic respiratory diseases |
title_short | Exacerbations of chronic respiratory diseases |
title_sort | exacerbations of chronic respiratory diseases |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173443/ http://dx.doi.org/10.1016/B978-0-12-816417-4.00006-8 |
work_keys_str_mv | AT edwardsmichaelr exacerbationsofchronicrespiratorydiseases AT ritchieandrewi exacerbationsofchronicrespiratorydiseases AT johnstonsebastianl exacerbationsofchronicrespiratorydiseases |