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At the Center of Autophagy: Autophagosomes
Autophagosomes are double-membrane sequestering vesicles that are the hallmark of the intracellular catabolic process called macroautophagy. They are formed by the orchestrated interplay of the AuTophaGy-related (ATG) proteins. The cargo molecules targeted by autophagosomes ranges from long-lived pr...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173568/ http://dx.doi.org/10.1016/B978-0-12-394447-4.20021-7 |
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author | Reggiori, F. Mauthe, M. |
author_facet | Reggiori, F. Mauthe, M. |
author_sort | Reggiori, F. |
collection | PubMed |
description | Autophagosomes are double-membrane sequestering vesicles that are the hallmark of the intracellular catabolic process called macroautophagy. They are formed by the orchestrated interplay of the AuTophaGy-related (ATG) proteins. The cargo molecules targeted by autophagosomes ranges from long-lived proteins and superfluous or excess organelles to invading pathogens. Autophagosomes finally fuse with lysosomes delivering the sequestered material in the interior of these organelles where it is degraded by resident hydrolases. Autophagy represents a key survival mechanism because it clears the cytoplasm from unwanted and potentially toxic structures, and the autophagosomes are the central stage of it. |
format | Online Article Text |
id | pubmed-7173568 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
record_format | MEDLINE/PubMed |
spelling | pubmed-71735682020-04-22 At the Center of Autophagy: Autophagosomes Reggiori, F. Mauthe, M. Encyclopedia of Cell Biology Article Autophagosomes are double-membrane sequestering vesicles that are the hallmark of the intracellular catabolic process called macroautophagy. They are formed by the orchestrated interplay of the AuTophaGy-related (ATG) proteins. The cargo molecules targeted by autophagosomes ranges from long-lived proteins and superfluous or excess organelles to invading pathogens. Autophagosomes finally fuse with lysosomes delivering the sequestered material in the interior of these organelles where it is degraded by resident hydrolases. Autophagy represents a key survival mechanism because it clears the cytoplasm from unwanted and potentially toxic structures, and the autophagosomes are the central stage of it. 2016 2015-08-20 /pmc/articles/PMC7173568/ http://dx.doi.org/10.1016/B978-0-12-394447-4.20021-7 Text en Copyright © 2016 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Reggiori, F. Mauthe, M. At the Center of Autophagy: Autophagosomes |
title | At the Center of Autophagy: Autophagosomes |
title_full | At the Center of Autophagy: Autophagosomes |
title_fullStr | At the Center of Autophagy: Autophagosomes |
title_full_unstemmed | At the Center of Autophagy: Autophagosomes |
title_short | At the Center of Autophagy: Autophagosomes |
title_sort | at the center of autophagy: autophagosomes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173568/ http://dx.doi.org/10.1016/B978-0-12-394447-4.20021-7 |
work_keys_str_mv | AT reggiorif atthecenterofautophagyautophagosomes AT mauthem atthecenterofautophagyautophagosomes |