PARP1-cGAS-NF-κB pathway of proinflammatory macrophage activation by extracellular vesicles released during Trypanosoma cruzi infection and Chagas disease

Trypanosoma cruzi (T. cruzi) is the etiological agent of Chagas cardiomyopathy. In the present study, we investigated the role of extracellular vesicles (Ev) in shaping the macrophage (Mφ) response in progressive Chagas disease (CD). We purified T. cruzi Ev (TcEv) from axenic parasite cultures, and...

Descripción completa

Detalles Bibliográficos
Autores principales: Choudhuri, Subhadip, Garg, Nisha Jain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173744/
https://www.ncbi.nlm.nih.gov/pubmed/32315358
http://dx.doi.org/10.1371/journal.ppat.1008474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173744/
https://www.ncbi.nlm.nih.gov/pubmed/32315358
http://dx.doi.org/10.1371/journal.ppat.1008474

Ejemplares similares