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Nanoparticle Drug Delivery System for Glioma and Its Efficacy Improvement Strategies: A Comprehensive Review
Gliomas are the most common tumor of the central nervous system. However, the presence of the brain barrier blocks the effective delivery of drugs and leads to the treatment failure of various drugs. The development of a nanoparticle drug delivery system (NDDS) can solve this problem. In this review...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173867/ https://www.ncbi.nlm.nih.gov/pubmed/32368041 http://dx.doi.org/10.2147/IJN.S243223 |
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author | Li, Jie Zhao, Jiaqian Tan, Tiantian Liu, Mengmeng Zeng, Zhaowu Zeng, Yiying Zhang, Lele Fu, Chaomei Chen, Dajing Xie, Tian |
author_facet | Li, Jie Zhao, Jiaqian Tan, Tiantian Liu, Mengmeng Zeng, Zhaowu Zeng, Yiying Zhang, Lele Fu, Chaomei Chen, Dajing Xie, Tian |
author_sort | Li, Jie |
collection | PubMed |
description | Gliomas are the most common tumor of the central nervous system. However, the presence of the brain barrier blocks the effective delivery of drugs and leads to the treatment failure of various drugs. The development of a nanoparticle drug delivery system (NDDS) can solve this problem. In this review, we summarized the brain barrier (including blood–brain barrier (BBB), blood–brain tumor barriers (BBTB), brain–cerebrospinal fluid barrier (BCB), and nose-to-brain barrier), NDDS of glioma (such as passive targeting systems, active targeting systems, and environmental responsive targeting systems), and NDDS efficacy improvement strategies and deficiencies. The research prospect of drug-targeted delivery systems for glioma is also discussed. |
format | Online Article Text |
id | pubmed-7173867 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-71738672020-05-04 Nanoparticle Drug Delivery System for Glioma and Its Efficacy Improvement Strategies: A Comprehensive Review Li, Jie Zhao, Jiaqian Tan, Tiantian Liu, Mengmeng Zeng, Zhaowu Zeng, Yiying Zhang, Lele Fu, Chaomei Chen, Dajing Xie, Tian Int J Nanomedicine Review Gliomas are the most common tumor of the central nervous system. However, the presence of the brain barrier blocks the effective delivery of drugs and leads to the treatment failure of various drugs. The development of a nanoparticle drug delivery system (NDDS) can solve this problem. In this review, we summarized the brain barrier (including blood–brain barrier (BBB), blood–brain tumor barriers (BBTB), brain–cerebrospinal fluid barrier (BCB), and nose-to-brain barrier), NDDS of glioma (such as passive targeting systems, active targeting systems, and environmental responsive targeting systems), and NDDS efficacy improvement strategies and deficiencies. The research prospect of drug-targeted delivery systems for glioma is also discussed. Dove 2020-04-17 /pmc/articles/PMC7173867/ /pubmed/32368041 http://dx.doi.org/10.2147/IJN.S243223 Text en © 2020 Li et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Li, Jie Zhao, Jiaqian Tan, Tiantian Liu, Mengmeng Zeng, Zhaowu Zeng, Yiying Zhang, Lele Fu, Chaomei Chen, Dajing Xie, Tian Nanoparticle Drug Delivery System for Glioma and Its Efficacy Improvement Strategies: A Comprehensive Review |
title | Nanoparticle Drug Delivery System for Glioma and Its Efficacy Improvement Strategies: A Comprehensive Review |
title_full | Nanoparticle Drug Delivery System for Glioma and Its Efficacy Improvement Strategies: A Comprehensive Review |
title_fullStr | Nanoparticle Drug Delivery System for Glioma and Its Efficacy Improvement Strategies: A Comprehensive Review |
title_full_unstemmed | Nanoparticle Drug Delivery System for Glioma and Its Efficacy Improvement Strategies: A Comprehensive Review |
title_short | Nanoparticle Drug Delivery System for Glioma and Its Efficacy Improvement Strategies: A Comprehensive Review |
title_sort | nanoparticle drug delivery system for glioma and its efficacy improvement strategies: a comprehensive review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173867/ https://www.ncbi.nlm.nih.gov/pubmed/32368041 http://dx.doi.org/10.2147/IJN.S243223 |
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