Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity

Chemokines and their receptors are orchestrators of cell migration in humans. Because dysregulation of the receptor-chemokine system leads to inflammation and cancer, both chemokines and receptors are highly sought therapeutic targets. Yet one of the barriers for their therapeutic targeting is the l...

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Detalles Bibliográficos
Autores principales: Ngo, Tony, Stephens, Bryan S., Gustavsson, Martin, Holden, Lauren G., Abagyan, Ruben, Handel, Tracy M., Kufareva, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173943/
https://www.ncbi.nlm.nih.gov/pubmed/32271748
http://dx.doi.org/10.1371/journal.pbio.3000656

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173943/
https://www.ncbi.nlm.nih.gov/pubmed/32271748
http://dx.doi.org/10.1371/journal.pbio.3000656

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