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Lactoferrin-containing immunocomplex mediates antitumor effects by resetting tumor-associated macrophages to M1 phenotype
BACKGROUND: Tumor-associated macrophages (TAMs) resemble M2-polarized cells with potent immunosuppressive activity and play a pivotal role in tumor growth and progression. Converting TAMs to proinflammatory M1-like phenotype is thus an attractive strategy for antitumor immunotherapy. METHODS: A mous...
Autores principales: | Dong, Hongliang, Yang, Yueyao, Gao, Chenhui, Sun, Hehe, Wang, Hongmin, Hong, Chao, Wang, Jun, Gong, Fangyuan, Gao, Xiaoming |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174070/ https://www.ncbi.nlm.nih.gov/pubmed/32217759 http://dx.doi.org/10.1136/jitc-2019-000339 |
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