Cargando…
[(18)F]THK5351 PET Imaging in Patients with Mild Cognitive Impairment
BACKGROUND AND PURPOSE: Mild cognitive impairment (MCI) is a condition with diverse clinical outcomes and subgroups. Here we investigated the topographic distribution of tau in vivo using the positron emission tomography (PET) tracer [(18)F]THK5351 in MCI subgroups. METHODS: This study included 96 p...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Neurological Association
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174126/ https://www.ncbi.nlm.nih.gov/pubmed/32319236 http://dx.doi.org/10.3988/jcn.2020.16.2.202 |
_version_ | 1783524570316144640 |
---|---|
author | Jeong, Hye Jin Lee, Hyon Lee, Sang-Yoon Seo, Seongho Park, Kee Hyung Lee, Yeong-Bae Shin, Dong Jin Kang, Jae Myeong Yeon, Byeong Kil Kang, Seung-Gul Cho, Jaelim Seong, Joon-Kyung Okamura, Nobuyuki Villemagne, Victor L. Na, Duk L. Noh, Young |
author_facet | Jeong, Hye Jin Lee, Hyon Lee, Sang-Yoon Seo, Seongho Park, Kee Hyung Lee, Yeong-Bae Shin, Dong Jin Kang, Jae Myeong Yeon, Byeong Kil Kang, Seung-Gul Cho, Jaelim Seong, Joon-Kyung Okamura, Nobuyuki Villemagne, Victor L. Na, Duk L. Noh, Young |
author_sort | Jeong, Hye Jin |
collection | PubMed |
description | BACKGROUND AND PURPOSE: Mild cognitive impairment (MCI) is a condition with diverse clinical outcomes and subgroups. Here we investigated the topographic distribution of tau in vivo using the positron emission tomography (PET) tracer [(18)F]THK5351 in MCI subgroups. METHODS: This study included 96 participants comprising 38 with amnestic MCI (aMCI), 21 with nonamnestic MCI (naMCI), and 37 with normal cognition (NC) who underwent 3.0-T MRI, [(18)F]THK5351 PET, and detailed neuropsychological tests. [(18)F]flutemetamol PET was also performed in 62 participants. The aMCI patients were further divided into three groups: 1) verbal-aMCI, only verbal memory impairment; 2) visual-aMCI, only visual memory impairment; and 3) both-aMCI, both visual and verbal memory impairment. Voxel-wise statistical analysis and region-of-interest -based analyses were performed to evaluate the retention of [(18)F]THK5351 in the MCI subgroups. Subgroup analysis of amyloid-positive and -negative MCI patients was also performed. Correlations between [(18)F]THK5351 retention and different neuropsychological tests were evaluated using statistical parametric mapping analyses. RESULTS: [(18)F]THK5351 retention in the lateral temporal, mesial temporal, parietal, frontal, posterior cingulate cortices and precuneus was significantly greater in aMCI patients than in NC subjects, whereas it did not differ significantly between naMCI and NC participants. [(18)F] THK5351 retention was greater in the both-aMCI group than in the verbal-aMCI and visualaMCI groups, and greater in amyloid-positive than amyloid-negative MCI patients. The cognitive function scores were significantly correlated with cortical [(18)F]THK5351 retention. CONCLUSIONS: [(18)F]THK5351 PET might be useful for identifying distinct topographic patterns of [(18)F]THK5351 retention in subgroups of MCI patients who are at greater risk of the progression to Alzheimer's dementia. |
format | Online Article Text |
id | pubmed-7174126 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Korean Neurological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-71741262020-04-23 [(18)F]THK5351 PET Imaging in Patients with Mild Cognitive Impairment Jeong, Hye Jin Lee, Hyon Lee, Sang-Yoon Seo, Seongho Park, Kee Hyung Lee, Yeong-Bae Shin, Dong Jin Kang, Jae Myeong Yeon, Byeong Kil Kang, Seung-Gul Cho, Jaelim Seong, Joon-Kyung Okamura, Nobuyuki Villemagne, Victor L. Na, Duk L. Noh, Young J Clin Neurol Original Article BACKGROUND AND PURPOSE: Mild cognitive impairment (MCI) is a condition with diverse clinical outcomes and subgroups. Here we investigated the topographic distribution of tau in vivo using the positron emission tomography (PET) tracer [(18)F]THK5351 in MCI subgroups. METHODS: This study included 96 participants comprising 38 with amnestic MCI (aMCI), 21 with nonamnestic MCI (naMCI), and 37 with normal cognition (NC) who underwent 3.0-T MRI, [(18)F]THK5351 PET, and detailed neuropsychological tests. [(18)F]flutemetamol PET was also performed in 62 participants. The aMCI patients were further divided into three groups: 1) verbal-aMCI, only verbal memory impairment; 2) visual-aMCI, only visual memory impairment; and 3) both-aMCI, both visual and verbal memory impairment. Voxel-wise statistical analysis and region-of-interest -based analyses were performed to evaluate the retention of [(18)F]THK5351 in the MCI subgroups. Subgroup analysis of amyloid-positive and -negative MCI patients was also performed. Correlations between [(18)F]THK5351 retention and different neuropsychological tests were evaluated using statistical parametric mapping analyses. RESULTS: [(18)F]THK5351 retention in the lateral temporal, mesial temporal, parietal, frontal, posterior cingulate cortices and precuneus was significantly greater in aMCI patients than in NC subjects, whereas it did not differ significantly between naMCI and NC participants. [(18)F] THK5351 retention was greater in the both-aMCI group than in the verbal-aMCI and visualaMCI groups, and greater in amyloid-positive than amyloid-negative MCI patients. The cognitive function scores were significantly correlated with cortical [(18)F]THK5351 retention. CONCLUSIONS: [(18)F]THK5351 PET might be useful for identifying distinct topographic patterns of [(18)F]THK5351 retention in subgroups of MCI patients who are at greater risk of the progression to Alzheimer's dementia. Korean Neurological Association 2020-04 2019-04-02 /pmc/articles/PMC7174126/ /pubmed/32319236 http://dx.doi.org/10.3988/jcn.2020.16.2.202 Text en Copyright © 2020 Korean Neurological Association http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Jeong, Hye Jin Lee, Hyon Lee, Sang-Yoon Seo, Seongho Park, Kee Hyung Lee, Yeong-Bae Shin, Dong Jin Kang, Jae Myeong Yeon, Byeong Kil Kang, Seung-Gul Cho, Jaelim Seong, Joon-Kyung Okamura, Nobuyuki Villemagne, Victor L. Na, Duk L. Noh, Young [(18)F]THK5351 PET Imaging in Patients with Mild Cognitive Impairment |
title | [(18)F]THK5351 PET Imaging in Patients with Mild Cognitive Impairment |
title_full | [(18)F]THK5351 PET Imaging in Patients with Mild Cognitive Impairment |
title_fullStr | [(18)F]THK5351 PET Imaging in Patients with Mild Cognitive Impairment |
title_full_unstemmed | [(18)F]THK5351 PET Imaging in Patients with Mild Cognitive Impairment |
title_short | [(18)F]THK5351 PET Imaging in Patients with Mild Cognitive Impairment |
title_sort | [(18)f]thk5351 pet imaging in patients with mild cognitive impairment |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174126/ https://www.ncbi.nlm.nih.gov/pubmed/32319236 http://dx.doi.org/10.3988/jcn.2020.16.2.202 |
work_keys_str_mv | AT jeonghyejin 18fthk5351petimaginginpatientswithmildcognitiveimpairment AT leehyon 18fthk5351petimaginginpatientswithmildcognitiveimpairment AT leesangyoon 18fthk5351petimaginginpatientswithmildcognitiveimpairment AT seoseongho 18fthk5351petimaginginpatientswithmildcognitiveimpairment AT parkkeehyung 18fthk5351petimaginginpatientswithmildcognitiveimpairment AT leeyeongbae 18fthk5351petimaginginpatientswithmildcognitiveimpairment AT shindongjin 18fthk5351petimaginginpatientswithmildcognitiveimpairment AT kangjaemyeong 18fthk5351petimaginginpatientswithmildcognitiveimpairment AT yeonbyeongkil 18fthk5351petimaginginpatientswithmildcognitiveimpairment AT kangseunggul 18fthk5351petimaginginpatientswithmildcognitiveimpairment AT chojaelim 18fthk5351petimaginginpatientswithmildcognitiveimpairment AT seongjoonkyung 18fthk5351petimaginginpatientswithmildcognitiveimpairment AT okamuranobuyuki 18fthk5351petimaginginpatientswithmildcognitiveimpairment AT villemagnevictorl 18fthk5351petimaginginpatientswithmildcognitiveimpairment AT nadukl 18fthk5351petimaginginpatientswithmildcognitiveimpairment AT nohyoung 18fthk5351petimaginginpatientswithmildcognitiveimpairment |