Cargando…
Smooth-muscle-derived WNT5A augments allergen-induced airway remodelling and Th2 type inflammation
Asthma is a heterogeneous disease characterized by chronic inflammation and structural changes in the airways. The airway smooth muscle (ASM) is responsible for airway narrowing and an important source of inflammatory mediators. We and others have previously shown that WNT5A mRNA and protein express...
Autores principales: | Koopmans, Tim, Hesse, Laura, Nawijn, Martijn C., Kumawat, Kuldeep, Menzen, Mark H., Sophie T. Bos, I., Smits, Ron, Bakker, Elvira R. M., van den Berge, Maarten, Koppelman, Gerard H., Guryev, Victor, Gosens, Reinoud |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174298/ https://www.ncbi.nlm.nih.gov/pubmed/32317758 http://dx.doi.org/10.1038/s41598-020-63741-x |
Ejemplares similares
-
Regulation of actin dynamics by WNT-5A: implications for human airway smooth muscle contraction
por: Koopmans, Tim, et al.
Publicado: (2016) -
TGF-β-Activated Kinase 1 (TAK1) Signaling Regulates TGF-β-Induced WNT-5A Expression in Airway Smooth Muscle Cells via Sp1 and β-Catenin
por: Kumawat, Kuldeep, et al.
Publicado: (2014) -
WNT-5A: signaling and functions in health and disease
por: Kumawat, Kuldeep, et al.
Publicado: (2015) -
β-Catenin Directs Nuclear Factor-κB p65 Output via CREB-Binding Protein/p300 in Human Airway Smooth Muscle
por: Koopmans, Tim, et al.
Publicado: (2017) -
PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells
por: Roscioni, Sara S, et al.
Publicado: (2009)