A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury

Renal tubular epithelial cells (RTECs) perform the essential function of maintaining the constancy of body fluid composition and volume. Toxic, inflammatory, or hypoxic-insults to RTECs can cause systemic fluid imbalance, electrolyte abnormalities and metabolic waste accumulation- manifesting as acu...

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Detalles Bibliográficos
Autores principales: Kim, Ji Young, Bai, Yuntao, Jayne, Laura A., Hector, Ralph D., Persaud, Avinash K., Ong, Su Sien, Rojesh, Shreshtha, Raj, Radhika, Feng, Mei Ji He Ho, Chung, Sangwoon, Cianciolo, Rachel E., Christman, John W., Campbell, Moray J., Gardner, David S., Baker, Sharyn D., Sparreboom, Alex, Govindarajan, Rajgopal, Singh, Harpreet, Chen, Taosheng, Poi, Ming, Susztak, Katalin, Cobb, Stuart R., Pabla, Navjot Singh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174303/
https://www.ncbi.nlm.nih.gov/pubmed/32317630
http://dx.doi.org/10.1038/s41467-020-15638-6

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