Cargando…
Insufficient Antigen Presentation Due to Viral Immune Evasion Explains Lethal Cytomegalovirus Organ Disease After Allogeneic Hematopoietic Cell Transplantation
Reactivation of latent cytomegalovirus (CMV) poses a clinical problem in transiently immunocompromised recipients of hematopoietic cell (HC) transplantation (HCT) by viral histopathology that results in multiple organ manifestations. Compared to autologous HCT and to syngeneic HCT performed with ide...
Autores principales: | Holtappels, Rafaela, Schader, Sina I., Oettel, Oliver, Podlech, Jürgen, Seckert, Christof K., Reddehase, Matthias J., Lemmermann, Niels A. W. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174590/ https://www.ncbi.nlm.nih.gov/pubmed/32351904 http://dx.doi.org/10.3389/fcimb.2020.00157 |
Ejemplares similares
-
Enhancement of Antigen Presentation by Deletion of Viral Immune Evasion Genes Prevents Lethal Cytomegalovirus Disease in Minor Histocompatibility Antigen-Mismatched Hematopoietic Cell Transplantation
por: Gezinir, Emin, et al.
Publicado: (2020) -
Consequence of Histoincompatibility beyond GvH-Reaction in Cytomegalovirus Disease Associated with Allogeneic Hematopoietic Cell Transplantation: Change of Paradigm
por: Reddehase, Matthias J., et al.
Publicado: (2021) -
Reconstitution of CD8 T Cells Protective against Cytomegalovirus in a Mouse Model of Hematopoietic Cell Transplantation: Dynamics and Inessentiality of Epitope Immunodominance
por: Holtappels, Rafaela, et al.
Publicado: (2016) -
Stochastic Episodes of Latent Cytomegalovirus Transcription Drive CD8 T-Cell “Memory Inflation” and Avoid Immune Evasion
por: Griessl, Marion, et al.
Publicado: (2021) -
Memory CD8 T Cells Protect against Cytomegalovirus Disease by Formation of Nodular Inflammatory Foci Preventing Intra-Tissue Virus Spread
por: Holtappels, Rafaela, et al.
Publicado: (2022)