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Nine Things Genomics Can Tell Us About Candida auris
Candida auris is a recently emerged multidrug-resistant fungal pathogen causing severe illness in hospitalized patients. C. auris is most closely related to a few environmental or rarely observed but cosmopolitan Candida species. However, C. auris is unique in the concern it is generating among publ...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174702/ https://www.ncbi.nlm.nih.gov/pubmed/32351544 http://dx.doi.org/10.3389/fgene.2020.00351 |
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author | Chybowska, Aleksandra D. Childers, Delma S. Farrer, Rhys A. |
author_facet | Chybowska, Aleksandra D. Childers, Delma S. Farrer, Rhys A. |
author_sort | Chybowska, Aleksandra D. |
collection | PubMed |
description | Candida auris is a recently emerged multidrug-resistant fungal pathogen causing severe illness in hospitalized patients. C. auris is most closely related to a few environmental or rarely observed but cosmopolitan Candida species. However, C. auris is unique in the concern it is generating among public health agencies for its rapid emergence, difficulty to treat, and the likelihood for further and more extensive outbreaks and spread. To date, five geographically distributed and genetically divergent lineages have been identified, none of which includes isolates that were collected prior to 1996. Indeed, C. auris’ ecological niche(s) and emergence remain enigmatic, although a number of hypotheses have been proposed. Recent genomic and transcriptomic work has also identified a variety of gene and chromosomal features that may have conferred C. auris with several important clinical phenotypes including its drug-resistance and growth at high temperatures. In this review we discuss nine major lines of enquiry into C. auris that big-data technologies and analytical approaches are beginning to answer. |
format | Online Article Text |
id | pubmed-7174702 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71747022020-04-29 Nine Things Genomics Can Tell Us About Candida auris Chybowska, Aleksandra D. Childers, Delma S. Farrer, Rhys A. Front Genet Genetics Candida auris is a recently emerged multidrug-resistant fungal pathogen causing severe illness in hospitalized patients. C. auris is most closely related to a few environmental or rarely observed but cosmopolitan Candida species. However, C. auris is unique in the concern it is generating among public health agencies for its rapid emergence, difficulty to treat, and the likelihood for further and more extensive outbreaks and spread. To date, five geographically distributed and genetically divergent lineages have been identified, none of which includes isolates that were collected prior to 1996. Indeed, C. auris’ ecological niche(s) and emergence remain enigmatic, although a number of hypotheses have been proposed. Recent genomic and transcriptomic work has also identified a variety of gene and chromosomal features that may have conferred C. auris with several important clinical phenotypes including its drug-resistance and growth at high temperatures. In this review we discuss nine major lines of enquiry into C. auris that big-data technologies and analytical approaches are beginning to answer. Frontiers Media S.A. 2020-04-15 /pmc/articles/PMC7174702/ /pubmed/32351544 http://dx.doi.org/10.3389/fgene.2020.00351 Text en Copyright © 2020 Chybowska, Childers and Farrer. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Chybowska, Aleksandra D. Childers, Delma S. Farrer, Rhys A. Nine Things Genomics Can Tell Us About Candida auris |
title | Nine Things Genomics Can Tell Us About Candida auris |
title_full | Nine Things Genomics Can Tell Us About Candida auris |
title_fullStr | Nine Things Genomics Can Tell Us About Candida auris |
title_full_unstemmed | Nine Things Genomics Can Tell Us About Candida auris |
title_short | Nine Things Genomics Can Tell Us About Candida auris |
title_sort | nine things genomics can tell us about candida auris |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174702/ https://www.ncbi.nlm.nih.gov/pubmed/32351544 http://dx.doi.org/10.3389/fgene.2020.00351 |
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