Synthesis and Biological Evaluation of HDAC Inhibitors With a Novel Zinc Binding Group

Vorinostat (SAHA) with great therapeutic potential has been approved by the FDA for the treatment of cutaneous T-cell lymphoma as the first HDACs inhibitor, but the drawbacks associated with hydroxamic acid group (poor stability, easy metabolism, weak binding ability to class IIa isozymes, and poor...

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Detalles Bibliográficos
Autores principales: He, Junquan, Wang, Songsong, Liu, Xingang, Lin, Ruili, Deng, Fang, Jia, Zhong, Zhang, Chenghong, Li, Zhao, Zhu, Hongtian, Tang, Lei, Yang, Pingrong, He, Dian, Jia, Qingzhong, Zhang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174758/
https://www.ncbi.nlm.nih.gov/pubmed/32351936
http://dx.doi.org/10.3389/fchem.2020.00256

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