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Atypical Manifestation of DRESS Syndrome
The differential for liver transaminases over 1000 units/liter typically includes liver ischemia, acute viral hepatitis, acetaminophen toxicity, and autoimmune hepatitis. Prompt evaluation is imperative as these etiologies can lead to fulminant liver failure. We present a case of transaminases over...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174907/ https://www.ncbi.nlm.nih.gov/pubmed/32328318 http://dx.doi.org/10.1155/2020/6863582 |
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author | Hakim, Christopher Melitas, Constantine Nguyen, Eric Ngo, Kha |
author_facet | Hakim, Christopher Melitas, Constantine Nguyen, Eric Ngo, Kha |
author_sort | Hakim, Christopher |
collection | PubMed |
description | The differential for liver transaminases over 1000 units/liter typically includes liver ischemia, acute viral hepatitis, acetaminophen toxicity, and autoimmune hepatitis. Prompt evaluation is imperative as these etiologies can lead to fulminant liver failure. We present a case of transaminases over 1000 units/liter from an atypical etiology. A 52-year-old male, previously treated with allopurinol for an acute gout flare, presented with persistent fevers. Given that he had taken a “high-risk medication” 2–6 weeks before presentation, subsequently presented with fever, rash, renal impairment, elevated liver enzymes in the thousands, and peripheral eosinophilia, DRESS syndrome secondary to allopurinol was diagnosed. |
format | Online Article Text |
id | pubmed-7174907 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-71749072020-04-23 Atypical Manifestation of DRESS Syndrome Hakim, Christopher Melitas, Constantine Nguyen, Eric Ngo, Kha Case Rep Gastrointest Med Case Report The differential for liver transaminases over 1000 units/liter typically includes liver ischemia, acute viral hepatitis, acetaminophen toxicity, and autoimmune hepatitis. Prompt evaluation is imperative as these etiologies can lead to fulminant liver failure. We present a case of transaminases over 1000 units/liter from an atypical etiology. A 52-year-old male, previously treated with allopurinol for an acute gout flare, presented with persistent fevers. Given that he had taken a “high-risk medication” 2–6 weeks before presentation, subsequently presented with fever, rash, renal impairment, elevated liver enzymes in the thousands, and peripheral eosinophilia, DRESS syndrome secondary to allopurinol was diagnosed. Hindawi 2020-04-12 /pmc/articles/PMC7174907/ /pubmed/32328318 http://dx.doi.org/10.1155/2020/6863582 Text en Copyright © 2020 Christopher Hakim et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Hakim, Christopher Melitas, Constantine Nguyen, Eric Ngo, Kha Atypical Manifestation of DRESS Syndrome |
title | Atypical Manifestation of DRESS Syndrome |
title_full | Atypical Manifestation of DRESS Syndrome |
title_fullStr | Atypical Manifestation of DRESS Syndrome |
title_full_unstemmed | Atypical Manifestation of DRESS Syndrome |
title_short | Atypical Manifestation of DRESS Syndrome |
title_sort | atypical manifestation of dress syndrome |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174907/ https://www.ncbi.nlm.nih.gov/pubmed/32328318 http://dx.doi.org/10.1155/2020/6863582 |
work_keys_str_mv | AT hakimchristopher atypicalmanifestationofdresssyndrome AT melitasconstantine atypicalmanifestationofdresssyndrome AT nguyeneric atypicalmanifestationofdresssyndrome AT ngokha atypicalmanifestationofdresssyndrome |