CD7-Positive Diffuse Large B-Cell Lymphoma Presenting as an Intranasal Tumor

We report a case of a 74-year-old man with a cluster of differentiation (CD) 7-positive diffuse large B-cell lymphoma (DLBCL) in the right nasal cavity. Flow cytometry analyses showed CD7 and CD20 positivity in tumor cells. The patient received 6 cycles of R-CHOP plus local radiation therapy because...

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Detalles Bibliográficos
Autores principales: Teshima, Kazuaki, Kume, Masaaki, Kawaharada, Yasushi, Saito, Takashi, Abe, Ko, Ikeda, Sho, Ohyagi, Hideaki, Zuguchi, Megumi, Zuguchi, Masashi, Kubota, Yosuke, Enomoto, Yoshitaka, Miura, Masahito, Takahashi, Satsuki, Saito, Masahiro, Saito, Ken, Takahashi, Naoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174964/
https://www.ncbi.nlm.nih.gov/pubmed/32328320
http://dx.doi.org/10.1155/2020/1514729
Descripción
Sumario:We report a case of a 74-year-old man with a cluster of differentiation (CD) 7-positive diffuse large B-cell lymphoma (DLBCL) in the right nasal cavity. Flow cytometry analyses showed CD7 and CD20 positivity in tumor cells. The patient received 6 cycles of R-CHOP plus local radiation therapy because positron emission tomography-computed tomography after R-CHOP revealed an intranasal lesion. The patient achieved complete remission (CR) after radiation therapy. The frequency of CD7-positive DLBCL is rare, and only 11 cases with follow-up of clinical course have been reported thus far. CR or partial response was noted in 8 of 11 cases after receiving rituximab combined with chemotherapy. In total, 9 of 12 cases involved the development of extranodal lesions, which occurred as an intranasal tumor in 3 cases. It is important to examine the clinical features by accumulation of further cases.

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