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Antimicrobial Properties on Non-Antibiotic Drugs in the Era of Increased Bacterial Resistance

In recent years, due to the dramatic increase in and global spread of bacterial resistance to a number of commonly used antibacterial agents, many studies have been directed at investigating drugs whose primary therapeutic purpose is not antimicrobial action. In an era where it is becoming increasin...

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Autores principales: Lagadinou, Maria, Onisor, Maria Octavia, Rigas, Athanasios, Musetescu, Daniel-Vasile, Gkentzi, Despoina, Assimakopoulos, Stelios F., Panos, George, Marangos, Markos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175110/
https://www.ncbi.nlm.nih.gov/pubmed/32131427
http://dx.doi.org/10.3390/antibiotics9030107
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author Lagadinou, Maria
Onisor, Maria Octavia
Rigas, Athanasios
Musetescu, Daniel-Vasile
Gkentzi, Despoina
Assimakopoulos, Stelios F.
Panos, George
Marangos, Markos
author_facet Lagadinou, Maria
Onisor, Maria Octavia
Rigas, Athanasios
Musetescu, Daniel-Vasile
Gkentzi, Despoina
Assimakopoulos, Stelios F.
Panos, George
Marangos, Markos
author_sort Lagadinou, Maria
collection PubMed
description In recent years, due to the dramatic increase in and global spread of bacterial resistance to a number of commonly used antibacterial agents, many studies have been directed at investigating drugs whose primary therapeutic purpose is not antimicrobial action. In an era where it is becoming increasingly difficult to find new antimicrobial drugs, it is important to understand these antimicrobial effects and their potential clinical implications. Numerous studies report the antibacterial activity of non-steroidal anti-inflammatory drugs, local anaesthetics, phenothiazines such as chlorpromazine, levomepromazine, promethazine, trifluoperazine, methdilazine and thioridazine, antidepressants, antiplatelets and statins. Several studies have explored a possible protective effect of statins inreducing the morbidity and mortality of many infectious diseases. Various non-antibiotic agents exhibit antimicrobial activity via multiple and different mechanisms of action. Further studies are required in the field to further investigate these antimicrobial properties in different populations. This is of paramount importance in the antimicrobial resistance era, where clinicians have limited therapeutic options to combat problematic infections.
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spelling pubmed-71751102020-04-28 Antimicrobial Properties on Non-Antibiotic Drugs in the Era of Increased Bacterial Resistance Lagadinou, Maria Onisor, Maria Octavia Rigas, Athanasios Musetescu, Daniel-Vasile Gkentzi, Despoina Assimakopoulos, Stelios F. Panos, George Marangos, Markos Antibiotics (Basel) Review In recent years, due to the dramatic increase in and global spread of bacterial resistance to a number of commonly used antibacterial agents, many studies have been directed at investigating drugs whose primary therapeutic purpose is not antimicrobial action. In an era where it is becoming increasingly difficult to find new antimicrobial drugs, it is important to understand these antimicrobial effects and their potential clinical implications. Numerous studies report the antibacterial activity of non-steroidal anti-inflammatory drugs, local anaesthetics, phenothiazines such as chlorpromazine, levomepromazine, promethazine, trifluoperazine, methdilazine and thioridazine, antidepressants, antiplatelets and statins. Several studies have explored a possible protective effect of statins inreducing the morbidity and mortality of many infectious diseases. Various non-antibiotic agents exhibit antimicrobial activity via multiple and different mechanisms of action. Further studies are required in the field to further investigate these antimicrobial properties in different populations. This is of paramount importance in the antimicrobial resistance era, where clinicians have limited therapeutic options to combat problematic infections. MDPI 2020-03-02 /pmc/articles/PMC7175110/ /pubmed/32131427 http://dx.doi.org/10.3390/antibiotics9030107 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lagadinou, Maria
Onisor, Maria Octavia
Rigas, Athanasios
Musetescu, Daniel-Vasile
Gkentzi, Despoina
Assimakopoulos, Stelios F.
Panos, George
Marangos, Markos
Antimicrobial Properties on Non-Antibiotic Drugs in the Era of Increased Bacterial Resistance
title Antimicrobial Properties on Non-Antibiotic Drugs in the Era of Increased Bacterial Resistance
title_full Antimicrobial Properties on Non-Antibiotic Drugs in the Era of Increased Bacterial Resistance
title_fullStr Antimicrobial Properties on Non-Antibiotic Drugs in the Era of Increased Bacterial Resistance
title_full_unstemmed Antimicrobial Properties on Non-Antibiotic Drugs in the Era of Increased Bacterial Resistance
title_short Antimicrobial Properties on Non-Antibiotic Drugs in the Era of Increased Bacterial Resistance
title_sort antimicrobial properties on non-antibiotic drugs in the era of increased bacterial resistance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175110/
https://www.ncbi.nlm.nih.gov/pubmed/32131427
http://dx.doi.org/10.3390/antibiotics9030107
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