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Antimicrobial Properties on Non-Antibiotic Drugs in the Era of Increased Bacterial Resistance
In recent years, due to the dramatic increase in and global spread of bacterial resistance to a number of commonly used antibacterial agents, many studies have been directed at investigating drugs whose primary therapeutic purpose is not antimicrobial action. In an era where it is becoming increasin...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175110/ https://www.ncbi.nlm.nih.gov/pubmed/32131427 http://dx.doi.org/10.3390/antibiotics9030107 |
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author | Lagadinou, Maria Onisor, Maria Octavia Rigas, Athanasios Musetescu, Daniel-Vasile Gkentzi, Despoina Assimakopoulos, Stelios F. Panos, George Marangos, Markos |
author_facet | Lagadinou, Maria Onisor, Maria Octavia Rigas, Athanasios Musetescu, Daniel-Vasile Gkentzi, Despoina Assimakopoulos, Stelios F. Panos, George Marangos, Markos |
author_sort | Lagadinou, Maria |
collection | PubMed |
description | In recent years, due to the dramatic increase in and global spread of bacterial resistance to a number of commonly used antibacterial agents, many studies have been directed at investigating drugs whose primary therapeutic purpose is not antimicrobial action. In an era where it is becoming increasingly difficult to find new antimicrobial drugs, it is important to understand these antimicrobial effects and their potential clinical implications. Numerous studies report the antibacterial activity of non-steroidal anti-inflammatory drugs, local anaesthetics, phenothiazines such as chlorpromazine, levomepromazine, promethazine, trifluoperazine, methdilazine and thioridazine, antidepressants, antiplatelets and statins. Several studies have explored a possible protective effect of statins inreducing the morbidity and mortality of many infectious diseases. Various non-antibiotic agents exhibit antimicrobial activity via multiple and different mechanisms of action. Further studies are required in the field to further investigate these antimicrobial properties in different populations. This is of paramount importance in the antimicrobial resistance era, where clinicians have limited therapeutic options to combat problematic infections. |
format | Online Article Text |
id | pubmed-7175110 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71751102020-04-28 Antimicrobial Properties on Non-Antibiotic Drugs in the Era of Increased Bacterial Resistance Lagadinou, Maria Onisor, Maria Octavia Rigas, Athanasios Musetescu, Daniel-Vasile Gkentzi, Despoina Assimakopoulos, Stelios F. Panos, George Marangos, Markos Antibiotics (Basel) Review In recent years, due to the dramatic increase in and global spread of bacterial resistance to a number of commonly used antibacterial agents, many studies have been directed at investigating drugs whose primary therapeutic purpose is not antimicrobial action. In an era where it is becoming increasingly difficult to find new antimicrobial drugs, it is important to understand these antimicrobial effects and their potential clinical implications. Numerous studies report the antibacterial activity of non-steroidal anti-inflammatory drugs, local anaesthetics, phenothiazines such as chlorpromazine, levomepromazine, promethazine, trifluoperazine, methdilazine and thioridazine, antidepressants, antiplatelets and statins. Several studies have explored a possible protective effect of statins inreducing the morbidity and mortality of many infectious diseases. Various non-antibiotic agents exhibit antimicrobial activity via multiple and different mechanisms of action. Further studies are required in the field to further investigate these antimicrobial properties in different populations. This is of paramount importance in the antimicrobial resistance era, where clinicians have limited therapeutic options to combat problematic infections. MDPI 2020-03-02 /pmc/articles/PMC7175110/ /pubmed/32131427 http://dx.doi.org/10.3390/antibiotics9030107 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lagadinou, Maria Onisor, Maria Octavia Rigas, Athanasios Musetescu, Daniel-Vasile Gkentzi, Despoina Assimakopoulos, Stelios F. Panos, George Marangos, Markos Antimicrobial Properties on Non-Antibiotic Drugs in the Era of Increased Bacterial Resistance |
title | Antimicrobial Properties on Non-Antibiotic Drugs in the Era of Increased Bacterial Resistance |
title_full | Antimicrobial Properties on Non-Antibiotic Drugs in the Era of Increased Bacterial Resistance |
title_fullStr | Antimicrobial Properties on Non-Antibiotic Drugs in the Era of Increased Bacterial Resistance |
title_full_unstemmed | Antimicrobial Properties on Non-Antibiotic Drugs in the Era of Increased Bacterial Resistance |
title_short | Antimicrobial Properties on Non-Antibiotic Drugs in the Era of Increased Bacterial Resistance |
title_sort | antimicrobial properties on non-antibiotic drugs in the era of increased bacterial resistance |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175110/ https://www.ncbi.nlm.nih.gov/pubmed/32131427 http://dx.doi.org/10.3390/antibiotics9030107 |
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