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Osseous Healing in Surgically Prepared Bone Defects Using Different Grafting Materials: An Experimental Study in Pigs
Regeneration of large jaw bone defects still remains a clinical challenge. To avoid incomplete bone repair, bone grafts have been advocated to support the healing process. This study comparatively evaluated new bone formation among a synthetic graft substitute, a human bone derivative, and a bovine...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175133/ https://www.ncbi.nlm.nih.gov/pubmed/31936576 http://dx.doi.org/10.3390/dj8010007 |
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author | Titsinides, Savvas Karatzas, Theodore Perrea, Despoina Eleftheriadis, Efstathios Podaropoulos, Leonidas Kalyvas, Demos Katopodis, Christos Agrogiannis, George |
author_facet | Titsinides, Savvas Karatzas, Theodore Perrea, Despoina Eleftheriadis, Efstathios Podaropoulos, Leonidas Kalyvas, Demos Katopodis, Christos Agrogiannis, George |
author_sort | Titsinides, Savvas |
collection | PubMed |
description | Regeneration of large jaw bone defects still remains a clinical challenge. To avoid incomplete bone repair, bone grafts have been advocated to support the healing process. This study comparatively evaluated new bone formation among a synthetic graft substitute, a human bone derivative, and a bovine xenograft. Materials were placed in 3 out of the 4 bone cavities, while 1 deficit was left empty, serving as a control, in mono-cortical defects, surgically prepared in the porcine calvaria bone. Animals were randomized in 2 groups and euthanized at 8 and 12 weeks. Harvested tissue specimens were qualitatively evaluated by histology. New bone formation was quantitatively measured by histomorphometry. Maximum new bone formation was noticed in defects grafted with beta-tricalcium phosphate b-TCP compared to the other bone substitutes, at 8 and 12 weeks post-surgery. Bovine and human allograft induced less new bone formation compared to empty bone cavity. Histologic analysis revealed that b-TCP was absorbed and substituted significantly, while bovine and human allograft was maintained almost intact in close proximity with new bone. Based on our findings, higher new bone formation was detected in defects filled with b-TCP when compared to bovine and human graft substitutes. |
format | Online Article Text |
id | pubmed-7175133 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71751332020-04-28 Osseous Healing in Surgically Prepared Bone Defects Using Different Grafting Materials: An Experimental Study in Pigs Titsinides, Savvas Karatzas, Theodore Perrea, Despoina Eleftheriadis, Efstathios Podaropoulos, Leonidas Kalyvas, Demos Katopodis, Christos Agrogiannis, George Dent J (Basel) Article Regeneration of large jaw bone defects still remains a clinical challenge. To avoid incomplete bone repair, bone grafts have been advocated to support the healing process. This study comparatively evaluated new bone formation among a synthetic graft substitute, a human bone derivative, and a bovine xenograft. Materials were placed in 3 out of the 4 bone cavities, while 1 deficit was left empty, serving as a control, in mono-cortical defects, surgically prepared in the porcine calvaria bone. Animals were randomized in 2 groups and euthanized at 8 and 12 weeks. Harvested tissue specimens were qualitatively evaluated by histology. New bone formation was quantitatively measured by histomorphometry. Maximum new bone formation was noticed in defects grafted with beta-tricalcium phosphate b-TCP compared to the other bone substitutes, at 8 and 12 weeks post-surgery. Bovine and human allograft induced less new bone formation compared to empty bone cavity. Histologic analysis revealed that b-TCP was absorbed and substituted significantly, while bovine and human allograft was maintained almost intact in close proximity with new bone. Based on our findings, higher new bone formation was detected in defects filled with b-TCP when compared to bovine and human graft substitutes. MDPI 2020-01-09 /pmc/articles/PMC7175133/ /pubmed/31936576 http://dx.doi.org/10.3390/dj8010007 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Titsinides, Savvas Karatzas, Theodore Perrea, Despoina Eleftheriadis, Efstathios Podaropoulos, Leonidas Kalyvas, Demos Katopodis, Christos Agrogiannis, George Osseous Healing in Surgically Prepared Bone Defects Using Different Grafting Materials: An Experimental Study in Pigs |
title | Osseous Healing in Surgically Prepared Bone Defects Using Different Grafting Materials: An Experimental Study in Pigs |
title_full | Osseous Healing in Surgically Prepared Bone Defects Using Different Grafting Materials: An Experimental Study in Pigs |
title_fullStr | Osseous Healing in Surgically Prepared Bone Defects Using Different Grafting Materials: An Experimental Study in Pigs |
title_full_unstemmed | Osseous Healing in Surgically Prepared Bone Defects Using Different Grafting Materials: An Experimental Study in Pigs |
title_short | Osseous Healing in Surgically Prepared Bone Defects Using Different Grafting Materials: An Experimental Study in Pigs |
title_sort | osseous healing in surgically prepared bone defects using different grafting materials: an experimental study in pigs |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175133/ https://www.ncbi.nlm.nih.gov/pubmed/31936576 http://dx.doi.org/10.3390/dj8010007 |
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