Acetylcholinesterase: The “Hub” for Neurodegenerative Diseases and Chemical Weapons Convention

This article describes acetylcholinesterase (AChE), an enzyme involved in parasympathetic neurotransmission, its activity, and how its inhibition can be pharmacologically useful for treating dementia, caused by Alzheimer’s disease, or as a warfare method due to the action of nerve agents. The chemic...

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Detalles Bibliográficos
Autores principales: Cavalcante, Samir F. de A., Simas, Alessandro B. C., Barcellos, Marcos C., de Oliveira, Victor G. M., Sousa, Roberto B., Cabral, Paulo A. de M., Kuča, Kamil, França, Tanos C. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175162/
https://www.ncbi.nlm.nih.gov/pubmed/32155996
http://dx.doi.org/10.3390/biom10030414
Descripción
Sumario:This article describes acetylcholinesterase (AChE), an enzyme involved in parasympathetic neurotransmission, its activity, and how its inhibition can be pharmacologically useful for treating dementia, caused by Alzheimer’s disease, or as a warfare method due to the action of nerve agents. The chemical concepts related to the irreversible inhibition of AChE, its reactivation, and aging are discussed, along with a relationship to the current international legislation on chemical weapons.

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