Acetylcholinesterase: The “Hub” for Neurodegenerative Diseases and Chemical Weapons Convention

This article describes acetylcholinesterase (AChE), an enzyme involved in parasympathetic neurotransmission, its activity, and how its inhibition can be pharmacologically useful for treating dementia, caused by Alzheimer’s disease, or as a warfare method due to the action of nerve agents. The chemic...

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Autores principales: Cavalcante, Samir F. de A., Simas, Alessandro B. C., Barcellos, Marcos C., de Oliveira, Victor G. M., Sousa, Roberto B., Cabral, Paulo A. de M., Kuča, Kamil, França, Tanos C. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175162/
https://www.ncbi.nlm.nih.gov/pubmed/32155996
http://dx.doi.org/10.3390/biom10030414
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author Cavalcante, Samir F. de A.
Simas, Alessandro B. C.
Barcellos, Marcos C.
de Oliveira, Victor G. M.
Sousa, Roberto B.
Cabral, Paulo A. de M.
Kuča, Kamil
França, Tanos C. C.
author_facet Cavalcante, Samir F. de A.
Simas, Alessandro B. C.
Barcellos, Marcos C.
de Oliveira, Victor G. M.
Sousa, Roberto B.
Cabral, Paulo A. de M.
Kuča, Kamil
França, Tanos C. C.
author_sort Cavalcante, Samir F. de A.
collection PubMed
description This article describes acetylcholinesterase (AChE), an enzyme involved in parasympathetic neurotransmission, its activity, and how its inhibition can be pharmacologically useful for treating dementia, caused by Alzheimer’s disease, or as a warfare method due to the action of nerve agents. The chemical concepts related to the irreversible inhibition of AChE, its reactivation, and aging are discussed, along with a relationship to the current international legislation on chemical weapons.
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spelling pubmed-71751622020-04-28 Acetylcholinesterase: The “Hub” for Neurodegenerative Diseases and Chemical Weapons Convention Cavalcante, Samir F. de A. Simas, Alessandro B. C. Barcellos, Marcos C. de Oliveira, Victor G. M. Sousa, Roberto B. Cabral, Paulo A. de M. Kuča, Kamil França, Tanos C. C. Biomolecules Review This article describes acetylcholinesterase (AChE), an enzyme involved in parasympathetic neurotransmission, its activity, and how its inhibition can be pharmacologically useful for treating dementia, caused by Alzheimer’s disease, or as a warfare method due to the action of nerve agents. The chemical concepts related to the irreversible inhibition of AChE, its reactivation, and aging are discussed, along with a relationship to the current international legislation on chemical weapons. MDPI 2020-03-07 /pmc/articles/PMC7175162/ /pubmed/32155996 http://dx.doi.org/10.3390/biom10030414 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cavalcante, Samir F. de A.
Simas, Alessandro B. C.
Barcellos, Marcos C.
de Oliveira, Victor G. M.
Sousa, Roberto B.
Cabral, Paulo A. de M.
Kuča, Kamil
França, Tanos C. C.
Acetylcholinesterase: The “Hub” for Neurodegenerative Diseases and Chemical Weapons Convention
title Acetylcholinesterase: The “Hub” for Neurodegenerative Diseases and Chemical Weapons Convention
title_full Acetylcholinesterase: The “Hub” for Neurodegenerative Diseases and Chemical Weapons Convention
title_fullStr Acetylcholinesterase: The “Hub” for Neurodegenerative Diseases and Chemical Weapons Convention
title_full_unstemmed Acetylcholinesterase: The “Hub” for Neurodegenerative Diseases and Chemical Weapons Convention
title_short Acetylcholinesterase: The “Hub” for Neurodegenerative Diseases and Chemical Weapons Convention
title_sort acetylcholinesterase: the “hub” for neurodegenerative diseases and chemical weapons convention
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175162/
https://www.ncbi.nlm.nih.gov/pubmed/32155996
http://dx.doi.org/10.3390/biom10030414
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