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A Strategy for Combinatorial Cavity Design in De Novo Proteins

Protein sequence space is vast; nature uses only an infinitesimal fraction of possible sequences to sustain life. Are there solutions to biological problems other than those provided by nature? Can we create artificial proteins that sustain life? To investigate these questions, we have created combi...

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Detalles Bibliográficos
Autores principales: Karas, Christina, Hecht, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175167/
https://www.ncbi.nlm.nih.gov/pubmed/31979320
http://dx.doi.org/10.3390/life10020009