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Role of p53 in the Regulation of Cellular Senescence

The p53 transcription factor plays a critical role in cellular responses to stress. Its activation in response to DNA damage leads to cell growth arrest, allowing for DNA repair, or directs cellular senescence or apoptosis, thereby maintaining genome integrity. Senescence is a permanent cell-cycle a...

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Detalles Bibliográficos
Autores principales:	Mijit, Mahmut, Caracciolo, Valentina, Melillo, Antonio, Amicarelli, Fernanda, Giordano, Antonio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175209/ https://www.ncbi.nlm.nih.gov/pubmed/32182711 http://dx.doi.org/10.3390/biom10030420

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