Rhodopsin: A Potential Biomarker for Neurodegenerative Diseases

Retinal alterations have recently been associated with numerous neurodegenerative diseases. Rhodopsin is a G-protein coupled receptor found in the rod cells of the retina. As a biomarker associated with retinal thinning and degeneration, it bears potential in the early detection and monitoring of se...

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Detalles Bibliográficos
Autores principales: Lenahan, Cameron, Sanghavi, Rajvee, Huang, Lei, Zhang, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175229/
https://www.ncbi.nlm.nih.gov/pubmed/32351353
http://dx.doi.org/10.3389/fnins.2020.00326
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author Lenahan, Cameron
Sanghavi, Rajvee
Huang, Lei
Zhang, John H.
author_facet Lenahan, Cameron
Sanghavi, Rajvee
Huang, Lei
Zhang, John H.
author_sort Lenahan, Cameron
collection PubMed
description Retinal alterations have recently been associated with numerous neurodegenerative diseases. Rhodopsin is a G-protein coupled receptor found in the rod cells of the retina. As a biomarker associated with retinal thinning and degeneration, it bears potential in the early detection and monitoring of several neurodegenerative diseases. In this review article, we summarize the findings of correlations between rhodopsin and several neurodegenerative disorders as well as the potential of a novel technique, cSLO, in the quantification of rhodopsin.
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spelling pubmed-71752292020-04-29 Rhodopsin: A Potential Biomarker for Neurodegenerative Diseases Lenahan, Cameron Sanghavi, Rajvee Huang, Lei Zhang, John H. Front Neurosci Neuroscience Retinal alterations have recently been associated with numerous neurodegenerative diseases. Rhodopsin is a G-protein coupled receptor found in the rod cells of the retina. As a biomarker associated with retinal thinning and degeneration, it bears potential in the early detection and monitoring of several neurodegenerative diseases. In this review article, we summarize the findings of correlations between rhodopsin and several neurodegenerative disorders as well as the potential of a novel technique, cSLO, in the quantification of rhodopsin. Frontiers Media S.A. 2020-04-15 /pmc/articles/PMC7175229/ /pubmed/32351353 http://dx.doi.org/10.3389/fnins.2020.00326 Text en Copyright © 2020 Lenahan, Sanghavi, Huang and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Lenahan, Cameron
Sanghavi, Rajvee
Huang, Lei
Zhang, John H.
Rhodopsin: A Potential Biomarker for Neurodegenerative Diseases
title Rhodopsin: A Potential Biomarker for Neurodegenerative Diseases
title_full Rhodopsin: A Potential Biomarker for Neurodegenerative Diseases
title_fullStr Rhodopsin: A Potential Biomarker for Neurodegenerative Diseases
title_full_unstemmed Rhodopsin: A Potential Biomarker for Neurodegenerative Diseases
title_short Rhodopsin: A Potential Biomarker for Neurodegenerative Diseases
title_sort rhodopsin: a potential biomarker for neurodegenerative diseases
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175229/
https://www.ncbi.nlm.nih.gov/pubmed/32351353
http://dx.doi.org/10.3389/fnins.2020.00326
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AT zhangjohnh rhodopsinapotentialbiomarkerforneurodegenerativediseases

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