Arterial Regeneration: Dimeric Thymosin β4 Loaded Nanofibrous Interface Enhanced Regeneration of Muscular Artery in Aging Body through Modulating Perivascular Adipose Stem Cell–Macrophage Interaction (Adv. Sci. 8/2020)

In article number https://doi.org/10.1002/advs.201903307, Cun Zhang, Wei Wu, and co‐workers identify the adult perivascular adipose tissue (PVAT) as the dominant source of vascular progenitors in a rat abdominal aorta model and clarify the mechanism by which DTβ4 enhances arterial muscle remodeling...

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Detalles Bibliográficos
Autores principales: Chen, Wanli, Jia, Sansan, Zhang, Xinchi, Zhang, Siqian, Liu, Huan, Yang, Xin, Zhang, Cun, Wu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175263/
http://dx.doi.org/10.1002/advs.202070045
Descripción
Sumario:In article number https://doi.org/10.1002/advs.201903307, Cun Zhang, Wei Wu, and co‐workers identify the adult perivascular adipose tissue (PVAT) as the dominant source of vascular progenitors in a rat abdominal aorta model and clarify the mechanism by which DTβ4 enhances arterial muscle remodeling in the aging body. Different from conventional synthetic grafts, DTβ4‐incorporated grafts exhibit enhanced vascular regenerative activity and effectively ameliorate aging induced defective regeneration, thus providing a rational strategy for clinical translation of vascular grafts. [Image: see text]

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