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A selective p38α/β MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5XFAD mouse

BACKGROUND: Chronic neuroinflammation, aggressive amyloid beta (Aβ) deposition, neuronal cell loss, and cognitive impairment are pathological presentations of Alzheimer’s disease (AD). Therefore, resolution of neuroinflammation and inhibition of Aβ-driven pathology have been suggested to be importan...

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Detalles Bibliográficos
Autores principales:	Gee, Min Sung, Son, Seung Hwan, Jeon, Seung Ho, Do, Jimin, Kim, Namkwon, Ju, Yeon-Joo, Lee, Soo Jin, Chung, Eun Kyoung, Inn, Kyung-Soo, Kim, Nam-Jung, Lee, Jong Kil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175487/ https://www.ncbi.nlm.nih.gov/pubmed/32317025 http://dx.doi.org/10.1186/s13195-020-00617-2

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