Enhanced inflammasome activation and reduced sphingosine-1 phosphate S1P signalling in a respiratory mucoobstructive disease model

BACKGROUND: Inflammasomes and sphingosine-1-phosphate (S1P) signalling are increasingly subject to intensive research in human diseases. We hypothesize that in respiratory muco-obstructive diseases, mucus obstruction enhances NLRP3 inflammasome activation and dysregulated S1P signalling. METHODS: Lu...

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Detalles Bibliográficos
Autores principales: Tran, Hai B., Macowan, Matthew G., Abdo, Adrian, Donnelley, Martin, Parsons, David, Hodge, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175514/
https://www.ncbi.nlm.nih.gov/pubmed/32336954
http://dx.doi.org/10.1186/s12950-020-00248-2

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