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Autophagy-mediated regulation of neutrophils and clinical applications
Autophagy, an adaptive catabolic process, plays a cytoprotective role in enabling cellular homeostasis in the innate and adaptive immune systems. Neutrophils, the most abundant immune cells in circulation, are professional killers that orchestrate a series of events during acute inflammation. The re...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175771/ https://www.ncbi.nlm.nih.gov/pubmed/32341923 http://dx.doi.org/10.1093/burnst/tkz001 |
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author | Yu, Yao Sun, Bingwei |
author_facet | Yu, Yao Sun, Bingwei |
author_sort | Yu, Yao |
collection | PubMed |
description | Autophagy, an adaptive catabolic process, plays a cytoprotective role in enabling cellular homeostasis in the innate and adaptive immune systems. Neutrophils, the most abundant immune cells in circulation, are professional killers that orchestrate a series of events during acute inflammation. The recent literature indicates that autophagy has important roles in regulating neutrophil functions, including differentiation, degranulation, metabolism and neutrophil extracellular trap formation, that dictate neutrophil fate. It is also becoming increasingly clear that autophagy regulation is critical for neutrophils to exert their immunological activity. However, evidence regarding the systematic communication between neutrophils and autophagy is insufficient. Here, we provide an updated overview of the function of autophagy as a regulator of neutrophils and discuss its clinical relevance to provide novel insight into potentially relevant treatment strategies. |
format | Online Article Text |
id | pubmed-7175771 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-71757712020-04-27 Autophagy-mediated regulation of neutrophils and clinical applications Yu, Yao Sun, Bingwei Burns Trauma Review Autophagy, an adaptive catabolic process, plays a cytoprotective role in enabling cellular homeostasis in the innate and adaptive immune systems. Neutrophils, the most abundant immune cells in circulation, are professional killers that orchestrate a series of events during acute inflammation. The recent literature indicates that autophagy has important roles in regulating neutrophil functions, including differentiation, degranulation, metabolism and neutrophil extracellular trap formation, that dictate neutrophil fate. It is also becoming increasingly clear that autophagy regulation is critical for neutrophils to exert their immunological activity. However, evidence regarding the systematic communication between neutrophils and autophagy is insufficient. Here, we provide an updated overview of the function of autophagy as a regulator of neutrophils and discuss its clinical relevance to provide novel insight into potentially relevant treatment strategies. Oxford University Press 2020-01-16 /pmc/articles/PMC7175771/ /pubmed/32341923 http://dx.doi.org/10.1093/burnst/tkz001 Text en © The Author(s) 2020. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Review Yu, Yao Sun, Bingwei Autophagy-mediated regulation of neutrophils and clinical applications |
title | Autophagy-mediated regulation of neutrophils and clinical applications |
title_full | Autophagy-mediated regulation of neutrophils and clinical applications |
title_fullStr | Autophagy-mediated regulation of neutrophils and clinical applications |
title_full_unstemmed | Autophagy-mediated regulation of neutrophils and clinical applications |
title_short | Autophagy-mediated regulation of neutrophils and clinical applications |
title_sort | autophagy-mediated regulation of neutrophils and clinical applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175771/ https://www.ncbi.nlm.nih.gov/pubmed/32341923 http://dx.doi.org/10.1093/burnst/tkz001 |
work_keys_str_mv | AT yuyao autophagymediatedregulationofneutrophilsandclinicalapplications AT sunbingwei autophagymediatedregulationofneutrophilsandclinicalapplications |