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Autophagy-mediated regulation of neutrophils and clinical applications

Autophagy, an adaptive catabolic process, plays a cytoprotective role in enabling cellular homeostasis in the innate and adaptive immune systems. Neutrophils, the most abundant immune cells in circulation, are professional killers that orchestrate a series of events during acute inflammation. The re...

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Detalles Bibliográficos
Autores principales: Yu, Yao, Sun, Bingwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175771/
https://www.ncbi.nlm.nih.gov/pubmed/32341923
http://dx.doi.org/10.1093/burnst/tkz001
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author Yu, Yao
Sun, Bingwei
author_facet Yu, Yao
Sun, Bingwei
author_sort Yu, Yao
collection PubMed
description Autophagy, an adaptive catabolic process, plays a cytoprotective role in enabling cellular homeostasis in the innate and adaptive immune systems. Neutrophils, the most abundant immune cells in circulation, are professional killers that orchestrate a series of events during acute inflammation. The recent literature indicates that autophagy has important roles in regulating neutrophil functions, including differentiation, degranulation, metabolism and neutrophil extracellular trap formation, that dictate neutrophil fate. It is also becoming increasingly clear that autophagy regulation is critical for neutrophils to exert their immunological activity. However, evidence regarding the systematic communication between neutrophils and autophagy is insufficient. Here, we provide an updated overview of the function of autophagy as a regulator of neutrophils and discuss its clinical relevance to provide novel insight into potentially relevant treatment strategies.
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spelling pubmed-71757712020-04-27 Autophagy-mediated regulation of neutrophils and clinical applications Yu, Yao Sun, Bingwei Burns Trauma Review Autophagy, an adaptive catabolic process, plays a cytoprotective role in enabling cellular homeostasis in the innate and adaptive immune systems. Neutrophils, the most abundant immune cells in circulation, are professional killers that orchestrate a series of events during acute inflammation. The recent literature indicates that autophagy has important roles in regulating neutrophil functions, including differentiation, degranulation, metabolism and neutrophil extracellular trap formation, that dictate neutrophil fate. It is also becoming increasingly clear that autophagy regulation is critical for neutrophils to exert their immunological activity. However, evidence regarding the systematic communication between neutrophils and autophagy is insufficient. Here, we provide an updated overview of the function of autophagy as a regulator of neutrophils and discuss its clinical relevance to provide novel insight into potentially relevant treatment strategies. Oxford University Press 2020-01-16 /pmc/articles/PMC7175771/ /pubmed/32341923 http://dx.doi.org/10.1093/burnst/tkz001 Text en © The Author(s) 2020. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Review
Yu, Yao
Sun, Bingwei
Autophagy-mediated regulation of neutrophils and clinical applications
title Autophagy-mediated regulation of neutrophils and clinical applications
title_full Autophagy-mediated regulation of neutrophils and clinical applications
title_fullStr Autophagy-mediated regulation of neutrophils and clinical applications
title_full_unstemmed Autophagy-mediated regulation of neutrophils and clinical applications
title_short Autophagy-mediated regulation of neutrophils and clinical applications
title_sort autophagy-mediated regulation of neutrophils and clinical applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175771/
https://www.ncbi.nlm.nih.gov/pubmed/32341923
http://dx.doi.org/10.1093/burnst/tkz001
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