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Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy

Over-expression of B7-H1 (PD-L1) molecule in the tumor microenvironment (TME) is a major immune evasion mechanism in some cancer patients and antibody blockade of the B7-H1/PD-1 interaction can normalize compromised immunity without excessive side-effects. Using a genome-scale T-cell activity array,...

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Detalles Bibliográficos
Autores principales:	Wang, Jun, Sun, Jingwei, Liu, Linda N., Flies, Dallas B., Nie, Xinxin, Toki, Maria, Zhang, Jianping, Song, Chang, Zarr, Melissa, Zhou, Xu, Han, Xue, Archer, Kristina A., O’Neill, Thomas, Herbst, Roy S., Boto, Agedi N., Sanmamed, Miguel F., Langermann, Solomon, Rimm, David L., Chen, Lieping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175920/ https://www.ncbi.nlm.nih.gov/pubmed/30833750 http://dx.doi.org/10.1038/s41591-019-0374-x

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