Development of the first in vivo GPR17 ligand through an iterative drug discovery pipeline: A novel disease-modifying strategy for multiple sclerosis

The GPR17 receptor, expressed on oligodendroglial precursors (OPCs, the myelin producing cells), has emerged as an attractive target for a pro-myelinating strategy in multiple sclerosis (MS). However, the proof-of-concept that selective GPR17 ligands actually exert protective activity in vivo is sti...

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Detalles Bibliográficos
Autores principales: Parravicini, Chiara, Lecca, Davide, Marangon, Davide, Coppolino, Giusy Tindara, Daniele, Simona, Bonfanti, Elisabetta, Fumagalli, Marta, Raveglia, Luca, Martini, Claudia, Gianazza, Elisabetta, Trincavelli, Maria Letizia, Abbracchio, Maria P., Eberini, Ivano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176092/
https://www.ncbi.nlm.nih.gov/pubmed/32320409
http://dx.doi.org/10.1371/journal.pone.0231483

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