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The novel multi-cytokine inhibitor TO-207 specifically inhibits pro-inflammatory cytokine secretion in monocytes without affecting the killing ability of CAR T cells

Cancer immunotherapy using chimeric antigen receptor–armed T (CAR T) cells have been shown to improve outcomes significantly in patients with hematological malignancies. However, cytokine release syndrome (CRS) remains a risk. CRS is characterized by the excessive activation of CAR T cells and macro...

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Detalles Bibliográficos
Autores principales:	Futami, Muneyoshi, Suzuki, Keisuke, Kato, Satomi, Ohmae, Saori, Tahara, Yoshio, Nojima, Masanori, Imai, Yoichi, Mimura, Takayuki, Watanabe, Yoshihiro, Tojo, Arinobu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176125/ https://www.ncbi.nlm.nih.gov/pubmed/32320454 http://dx.doi.org/10.1371/journal.pone.0231896

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