Cargando…
Signaling Pathways of SARS-CoV In Vitro and In Vivo
Severe acute respiratory syndrome (SARS) is a respiratory illness with variable symptoms that was recognized as the first near-pandemic infectious disease of the twenty-first century. A novel human coronavirus, named SARS coronavirus (SARS-CoV), derived from SARS patients was reported as the etiolog...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176218/ http://dx.doi.org/10.1007/978-3-642-03683-5_19 |
_version_ | 1783524979345719296 |
---|---|
author | Mizutani, Tetsuya |
author_facet | Mizutani, Tetsuya |
author_sort | Mizutani, Tetsuya |
collection | PubMed |
description | Severe acute respiratory syndrome (SARS) is a respiratory illness with variable symptoms that was recognized as the first near-pandemic infectious disease of the twenty-first century. A novel human coronavirus, named SARS coronavirus (SARS-CoV), derived from SARS patients was reported as the etiologic agent of SARS. Studying the signaling pathways of SARS-infected cells is key to understanding the molecular mechanism of SARS viral infection. Cell death is observed in cultured Vero E6 cells after SARS-CoV infection. From SARS-CoV infection to cell death, p38 mitogen-activated protein kinase (MAPK) is a key participant in the determination of cell death and survival. Two signaling pathways comprising signal transducer and activator of transcription 3 (STAT3) and p90 ribosomal S6 kinase (p90RSK) are downstream of p38 MAPK. AKT and JNK (Jun NH(2)-terminal kinase) signaling pathways are important to establish persistent infection of SARS-CoV in Vero E6 cells. Expression studies of SARS-CoV proteins indicate that the viral proteins are able to activate signaling pathways of host cells. The study of signaling pathways in SARS-CoV patients is difficult to perform compared with in vitro studies due to the effects of the human immune system. This review highlights recent progress in characterizing signal transduction pathways in SARS-CoV-infected cells in vitro and in vivo. |
format | Online Article Text |
id | pubmed-7176218 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
record_format | MEDLINE/PubMed |
spelling | pubmed-71762182020-04-22 Signaling Pathways of SARS-CoV In Vitro and In Vivo Mizutani, Tetsuya Molecular Biology of the SARS-Coronavirus Article Severe acute respiratory syndrome (SARS) is a respiratory illness with variable symptoms that was recognized as the first near-pandemic infectious disease of the twenty-first century. A novel human coronavirus, named SARS coronavirus (SARS-CoV), derived from SARS patients was reported as the etiologic agent of SARS. Studying the signaling pathways of SARS-infected cells is key to understanding the molecular mechanism of SARS viral infection. Cell death is observed in cultured Vero E6 cells after SARS-CoV infection. From SARS-CoV infection to cell death, p38 mitogen-activated protein kinase (MAPK) is a key participant in the determination of cell death and survival. Two signaling pathways comprising signal transducer and activator of transcription 3 (STAT3) and p90 ribosomal S6 kinase (p90RSK) are downstream of p38 MAPK. AKT and JNK (Jun NH(2)-terminal kinase) signaling pathways are important to establish persistent infection of SARS-CoV in Vero E6 cells. Expression studies of SARS-CoV proteins indicate that the viral proteins are able to activate signaling pathways of host cells. The study of signaling pathways in SARS-CoV patients is difficult to perform compared with in vitro studies due to the effects of the human immune system. This review highlights recent progress in characterizing signal transduction pathways in SARS-CoV-infected cells in vitro and in vivo. 2009-07-22 /pmc/articles/PMC7176218/ http://dx.doi.org/10.1007/978-3-642-03683-5_19 Text en © Springer-Verlag Berlin Heidelberg 2010 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Mizutani, Tetsuya Signaling Pathways of SARS-CoV In Vitro and In Vivo |
title | Signaling Pathways of SARS-CoV In Vitro and In Vivo |
title_full | Signaling Pathways of SARS-CoV In Vitro and In Vivo |
title_fullStr | Signaling Pathways of SARS-CoV In Vitro and In Vivo |
title_full_unstemmed | Signaling Pathways of SARS-CoV In Vitro and In Vivo |
title_short | Signaling Pathways of SARS-CoV In Vitro and In Vivo |
title_sort | signaling pathways of sars-cov in vitro and in vivo |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176218/ http://dx.doi.org/10.1007/978-3-642-03683-5_19 |
work_keys_str_mv | AT mizutanitetsuya signalingpathwaysofsarscovinvitroandinvivo |