Inhibitors of Hydrolases with an Acyl–Enzyme Intermediate

Peptidases and esterases are hydrolytic enzymes; 2–3% of all gene products are assigned to this group alone. They are therefore, an important group of target proteins for the design of new medicines and have a special importance for structure-based drug design. This is reflected in the fact that abo...

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Autor principal: Klebe, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176293/
http://dx.doi.org/10.1007/978-3-642-17907-5_23
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author Klebe, Gerhard
author_facet Klebe, Gerhard
author_sort Klebe, Gerhard
collection PubMed
description Peptidases and esterases are hydrolytic enzymes; 2–3% of all gene products are assigned to this group alone. They are therefore, an important group of target proteins for the design of new medicines and have a special importance for structure-based drug design. This is reflected in the fact that about 14% of all known human peptidases are presently being investigated as possible target structures for drug therapy.
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spelling pubmed-71762932020-04-22 Inhibitors of Hydrolases with an Acyl–Enzyme Intermediate Klebe, Gerhard Drug Design Article Peptidases and esterases are hydrolytic enzymes; 2–3% of all gene products are assigned to this group alone. They are therefore, an important group of target proteins for the design of new medicines and have a special importance for structure-based drug design. This is reflected in the fact that about 14% of all known human peptidases are presently being investigated as possible target structures for drug therapy. 2013 /pmc/articles/PMC7176293/ http://dx.doi.org/10.1007/978-3-642-17907-5_23 Text en © Springer-Verlag Berlin Heidelberg 2013 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Klebe, Gerhard
Inhibitors of Hydrolases with an Acyl–Enzyme Intermediate
title Inhibitors of Hydrolases with an Acyl–Enzyme Intermediate
title_full Inhibitors of Hydrolases with an Acyl–Enzyme Intermediate
title_fullStr Inhibitors of Hydrolases with an Acyl–Enzyme Intermediate
title_full_unstemmed Inhibitors of Hydrolases with an Acyl–Enzyme Intermediate
title_short Inhibitors of Hydrolases with an Acyl–Enzyme Intermediate
title_sort inhibitors of hydrolases with an acyl–enzyme intermediate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176293/
http://dx.doi.org/10.1007/978-3-642-17907-5_23
work_keys_str_mv AT klebegerhard inhibitorsofhydrolaseswithanacylenzymeintermediate

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