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Endothelin-1 Mediates the Systemic and Renal Hemodynamic Effects of GPR81 Activation

GPR81 (G-protein-coupled receptor 81) is highly expressed in adipocytes, and activation by the endogenous ligand lactate inhibits lipolysis. GPR81 is also expressed in the heart, liver, and kidney, but roles in nonadipose tissues are poorly defined. GPR81 agonists, developed to improve blood lipid p...

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Detalles Bibliográficos
Autores principales:	Jones, Natalie K., Stewart, Kevin, Czopek, Alicja, Menzies, Robert I., Thomson, Adrian, Moran, Carmel M., Cairns, Carolynn, Conway, Bryan R., Denby, Laura, Livingstone, Dawn E.W., Wiseman, John, Hadoke, Patrick W., Webb, David J., Dhaun, Neeraj, Dear, James W., Mullins, John J., Bailey, Matthew A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott, Williams & Wilkins 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176350/ https://www.ncbi.nlm.nih.gov/pubmed/32200679 http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.14308

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