N6-adenosine methylation of ribosomal RNA affects lipid oxidation and stress resistance

During stress, global translation is reduced, but specific transcripts are actively translated. How stress-responsive mRNAs are selectively translated is unknown. We show that METL-5 methylates adenosine 1717 on 18S ribosomal RNA in C. elegans, enhancing selective ribosomal binding and translation o...

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Detalles Bibliográficos
Autores principales: Liberman, Noa, O’Brown, Zach K., Earl, Andrew Scott, Boulias, Konstantinos, Gerashchenko, Maxim V., Wang, Simon Yuan, Fritsche, Colette, Fady, Paul-Enguerrand, Dong, Anna, Gladyshev, Vadim N., Greer, Eric Lieberman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176415/
https://www.ncbi.nlm.nih.gov/pubmed/32494643
http://dx.doi.org/10.1126/sciadv.aaz4370

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