Partial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylation

We previously showed that NUDT21-spanning copy-number variations (CNVs) are associated with intellectual disability (Gennarino et al., 2015). However, the patients’ CNVs also included other genes. To determine if reduced NUDT21 function alone can cause disease, we generated Nudt21(+/-) mice to mimic...

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Detalles Bibliográficos
Autores principales: Alcott, Callison E, Yalamanchili, Hari Krishna, Ji, Ping, van der Heijden, Meike E, Saltzman, Alexander, Elrod, Nathan, Lin, Ai, Leng, Mei, Bhatt, Bhoomi, Hao, Shuang, Wang, Qi, Saliba, Afaf, Tang, Jianrong, Malovannaya, Anna, Wagner, Eric J, Liu, Zhandong, Zoghbi, Huda Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176433/
https://www.ncbi.nlm.nih.gov/pubmed/32319885
http://dx.doi.org/10.7554/eLife.50895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176433/
https://www.ncbi.nlm.nih.gov/pubmed/32319885
http://dx.doi.org/10.7554/eLife.50895

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