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Chemokine-like factor-like MARVEL transmembrane domain-containing family in autoimmune diseases

The chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM) is widely expressed in the immune system. Abnormal expression of CMTM is associated with the development of various diseases. This article summarizes the relevant research on the role of the CMTM family in imm...

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Autores principales: Duan, Hong-Ji, Li, Xin-Yi, Liu, Chang, Deng, Xiao-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176445/
https://www.ncbi.nlm.nih.gov/pubmed/32195671
http://dx.doi.org/10.1097/CM9.0000000000000747
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author Duan, Hong-Ji
Li, Xin-Yi
Liu, Chang
Deng, Xiao-Li
author_facet Duan, Hong-Ji
Li, Xin-Yi
Liu, Chang
Deng, Xiao-Li
author_sort Duan, Hong-Ji
collection PubMed
description The chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM) is widely expressed in the immune system. Abnormal expression of CMTM is associated with the development of various diseases. This article summarizes the relevant research on the role of the CMTM family in immune disorders. This information will increase our understanding of pathogenesis and identify promising targets for the diagnosis and treatment of autoimmune diseases. The CMTM family is highly expressed in peripheral blood mononuclear cells. CKLF1 may be involved in the development of arthritis through its interaction with C-C chemokine receptor 4. CKLF1 is associated with the pathogenesis of lupus nephritis and psoriasis. Both CMTM4 and CMTM5 are associated with the pathogenesis of systemic lupus erythematosus. CMTM1, CMTM2, CMTM3, and CMTM6 play a role in rheumatoid arthritis, systemic sclerosis, Sjögren syndrome, and anti-phospholipid syndrome, respectively. The CMTM family has been implicated in various autoimmune diseases. Further research on the mechanism of the action of CMTM family members may lead to the development of new treatment strategies for autoimmune diseases.
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spelling pubmed-71764452020-05-04 Chemokine-like factor-like MARVEL transmembrane domain-containing family in autoimmune diseases Duan, Hong-Ji Li, Xin-Yi Liu, Chang Deng, Xiao-Li Chin Med J (Engl) Review Articles The chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM) is widely expressed in the immune system. Abnormal expression of CMTM is associated with the development of various diseases. This article summarizes the relevant research on the role of the CMTM family in immune disorders. This information will increase our understanding of pathogenesis and identify promising targets for the diagnosis and treatment of autoimmune diseases. The CMTM family is highly expressed in peripheral blood mononuclear cells. CKLF1 may be involved in the development of arthritis through its interaction with C-C chemokine receptor 4. CKLF1 is associated with the pathogenesis of lupus nephritis and psoriasis. Both CMTM4 and CMTM5 are associated with the pathogenesis of systemic lupus erythematosus. CMTM1, CMTM2, CMTM3, and CMTM6 play a role in rheumatoid arthritis, systemic sclerosis, Sjögren syndrome, and anti-phospholipid syndrome, respectively. The CMTM family has been implicated in various autoimmune diseases. Further research on the mechanism of the action of CMTM family members may lead to the development of new treatment strategies for autoimmune diseases. Wolters Kluwer Health 2020-04-20 2020-04-20 /pmc/articles/PMC7176445/ /pubmed/32195671 http://dx.doi.org/10.1097/CM9.0000000000000747 Text en Copyright © 2020 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Review Articles
Duan, Hong-Ji
Li, Xin-Yi
Liu, Chang
Deng, Xiao-Li
Chemokine-like factor-like MARVEL transmembrane domain-containing family in autoimmune diseases
title Chemokine-like factor-like MARVEL transmembrane domain-containing family in autoimmune diseases
title_full Chemokine-like factor-like MARVEL transmembrane domain-containing family in autoimmune diseases
title_fullStr Chemokine-like factor-like MARVEL transmembrane domain-containing family in autoimmune diseases
title_full_unstemmed Chemokine-like factor-like MARVEL transmembrane domain-containing family in autoimmune diseases
title_short Chemokine-like factor-like MARVEL transmembrane domain-containing family in autoimmune diseases
title_sort chemokine-like factor-like marvel transmembrane domain-containing family in autoimmune diseases
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176445/
https://www.ncbi.nlm.nih.gov/pubmed/32195671
http://dx.doi.org/10.1097/CM9.0000000000000747
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