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Anti-reflux Surgery Versus Proton Pump Inhibitors for Severe Gastroesophageal Reflux Disease: A Cost-Effectiveness Study in Korea
BACKGROUND/AIMS: The economic burden for gastroesophageal reflux disease (GERD) has recently increased in Asian countries. This study investigates the cost-effectiveness between anti-reflux surgery and medication, with proton pump inhibitors (PPIs) for GERD in Korea. METHODS: We used a decision tree...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Society of Neurogastroenterology and Motility
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176505/ https://www.ncbi.nlm.nih.gov/pubmed/32235028 http://dx.doi.org/10.5056/jnm19188 |
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author | Park, Susan Park, Sungsoo Park, Joong-Min Ryu, Soorack Hwang, Jinseub Kwon, Jin-Won Seo, Kyung Won |
author_facet | Park, Susan Park, Sungsoo Park, Joong-Min Ryu, Soorack Hwang, Jinseub Kwon, Jin-Won Seo, Kyung Won |
author_sort | Park, Susan |
collection | PubMed |
description | BACKGROUND/AIMS: The economic burden for gastroesophageal reflux disease (GERD) has recently increased in Asian countries. This study investigates the cost-effectiveness between anti-reflux surgery and medication, with proton pump inhibitors (PPIs) for GERD in Korea. METHODS: We used a decision tree and Markov model to obtain the costs and quality-adjusted life years (QALYs) of the surgical and medical strategies. Our target cohort was the severe GERD patients aged 50 years old who required a continuous double dose of PPIs. The time horizon was 10 years and all estimates were discounted at 5% per year. The incremental cost-effectiveness ratio of the anti-reflux surgery compared with medication with PPIs was calculated. Sensitivity analyses were performed on all relevant variables. RESULTS: The cost-utility analysis indicated anti-reflux surgery was more cost-effective than medication among severe GERD patients over a 10year period. The model predicted that the surgical strategy had a cost savings of $551 and the QALYs had a gain of 1.18 as compared with the medical strategy. The break-even point in costs of the anti-reflux surgery over the medication was estimated to be 9 years. Sensitivity analyses using the varying parameter assumptions demonstrated the robustness of the study results. CONCLUSIONS: This study showed anti-reflux surgery was less expensive and more effective therapy over the PPI medication after 9 years of follow-up. This suggests the surgical strategy is a cost-effective alternative to PPI medication among patients who need long-term management for GERD in Korea. |
format | Online Article Text |
id | pubmed-7176505 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Korean Society of Neurogastroenterology and Motility |
record_format | MEDLINE/PubMed |
spelling | pubmed-71765052020-04-30 Anti-reflux Surgery Versus Proton Pump Inhibitors for Severe Gastroesophageal Reflux Disease: A Cost-Effectiveness Study in Korea Park, Susan Park, Sungsoo Park, Joong-Min Ryu, Soorack Hwang, Jinseub Kwon, Jin-Won Seo, Kyung Won J Neurogastroenterol Motil Original Article BACKGROUND/AIMS: The economic burden for gastroesophageal reflux disease (GERD) has recently increased in Asian countries. This study investigates the cost-effectiveness between anti-reflux surgery and medication, with proton pump inhibitors (PPIs) for GERD in Korea. METHODS: We used a decision tree and Markov model to obtain the costs and quality-adjusted life years (QALYs) of the surgical and medical strategies. Our target cohort was the severe GERD patients aged 50 years old who required a continuous double dose of PPIs. The time horizon was 10 years and all estimates were discounted at 5% per year. The incremental cost-effectiveness ratio of the anti-reflux surgery compared with medication with PPIs was calculated. Sensitivity analyses were performed on all relevant variables. RESULTS: The cost-utility analysis indicated anti-reflux surgery was more cost-effective than medication among severe GERD patients over a 10year period. The model predicted that the surgical strategy had a cost savings of $551 and the QALYs had a gain of 1.18 as compared with the medical strategy. The break-even point in costs of the anti-reflux surgery over the medication was estimated to be 9 years. Sensitivity analyses using the varying parameter assumptions demonstrated the robustness of the study results. CONCLUSIONS: This study showed anti-reflux surgery was less expensive and more effective therapy over the PPI medication after 9 years of follow-up. This suggests the surgical strategy is a cost-effective alternative to PPI medication among patients who need long-term management for GERD in Korea. The Korean Society of Neurogastroenterology and Motility 2020-04-30 2020-04-30 /pmc/articles/PMC7176505/ /pubmed/32235028 http://dx.doi.org/10.5056/jnm19188 Text en © 2020 The Korean Society of Neurogastroenterology and Motility This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Park, Susan Park, Sungsoo Park, Joong-Min Ryu, Soorack Hwang, Jinseub Kwon, Jin-Won Seo, Kyung Won Anti-reflux Surgery Versus Proton Pump Inhibitors for Severe Gastroesophageal Reflux Disease: A Cost-Effectiveness Study in Korea |
title | Anti-reflux Surgery Versus Proton Pump Inhibitors for Severe Gastroesophageal Reflux Disease: A Cost-Effectiveness Study in Korea |
title_full | Anti-reflux Surgery Versus Proton Pump Inhibitors for Severe Gastroesophageal Reflux Disease: A Cost-Effectiveness Study in Korea |
title_fullStr | Anti-reflux Surgery Versus Proton Pump Inhibitors for Severe Gastroesophageal Reflux Disease: A Cost-Effectiveness Study in Korea |
title_full_unstemmed | Anti-reflux Surgery Versus Proton Pump Inhibitors for Severe Gastroesophageal Reflux Disease: A Cost-Effectiveness Study in Korea |
title_short | Anti-reflux Surgery Versus Proton Pump Inhibitors for Severe Gastroesophageal Reflux Disease: A Cost-Effectiveness Study in Korea |
title_sort | anti-reflux surgery versus proton pump inhibitors for severe gastroesophageal reflux disease: a cost-effectiveness study in korea |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176505/ https://www.ncbi.nlm.nih.gov/pubmed/32235028 http://dx.doi.org/10.5056/jnm19188 |
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