Inhibition of melanin production by anthracenone dimer glycosides isolated from Cassia auriculata seeds

The methanol extract of Cassia auriculata seeds was found to inhibit melanogenesis in B16 melanoma 4A5 cells under conditions of theophylline stimulation. Two new phlegmacin-type anthracenone dimer glycosides, auriculataosides A and B, were isolated from the active methanol fraction, and their inhib...

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Autores principales: Wang, Weicheng, Zhang, Yi, Nakashima, Souichi, Nakamura, Seikou, Wang, Tao, Yoshikawa, Masayuki, Matsuda, Hisashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2019
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176596/
https://www.ncbi.nlm.nih.gov/pubmed/30847755
http://dx.doi.org/10.1007/s11418-018-01276-2
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author Wang, Weicheng
Zhang, Yi
Nakashima, Souichi
Nakamura, Seikou
Wang, Tao
Yoshikawa, Masayuki
Matsuda, Hisashi
author_facet Wang, Weicheng
Zhang, Yi
Nakashima, Souichi
Nakamura, Seikou
Wang, Tao
Yoshikawa, Masayuki
Matsuda, Hisashi
author_sort Wang, Weicheng
collection PubMed
description The methanol extract of Cassia auriculata seeds was found to inhibit melanogenesis in B16 melanoma 4A5 cells under conditions of theophylline stimulation. Two new phlegmacin-type anthracenone dimer glycosides, auriculataosides A and B, were isolated from the active methanol fraction, and their inhibitory effects were observed in the concentration range of 0.03 to 0.3 μM. Inhibition of microphthalmia-associated transcription factor, tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2 protein expression was observed, suggesting that the inhibition of these factors is part of the mechanism of action underlying melanogenesis inhibition. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11418-018-01276-2) contains supplementary material, which is available to authorized users.
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spelling pubmed-71765962020-04-28 Inhibition of melanin production by anthracenone dimer glycosides isolated from Cassia auriculata seeds Wang, Weicheng Zhang, Yi Nakashima, Souichi Nakamura, Seikou Wang, Tao Yoshikawa, Masayuki Matsuda, Hisashi J Nat Med Original Paper The methanol extract of Cassia auriculata seeds was found to inhibit melanogenesis in B16 melanoma 4A5 cells under conditions of theophylline stimulation. Two new phlegmacin-type anthracenone dimer glycosides, auriculataosides A and B, were isolated from the active methanol fraction, and their inhibitory effects were observed in the concentration range of 0.03 to 0.3 μM. Inhibition of microphthalmia-associated transcription factor, tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2 protein expression was observed, suggesting that the inhibition of these factors is part of the mechanism of action underlying melanogenesis inhibition. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11418-018-01276-2) contains supplementary material, which is available to authorized users. Springer Singapore 2019-03-07 2019 /pmc/articles/PMC7176596/ /pubmed/30847755 http://dx.doi.org/10.1007/s11418-018-01276-2 Text en © The Author(s) 2019, corrected publication 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Paper
Wang, Weicheng
Zhang, Yi
Nakashima, Souichi
Nakamura, Seikou
Wang, Tao
Yoshikawa, Masayuki
Matsuda, Hisashi
Inhibition of melanin production by anthracenone dimer glycosides isolated from Cassia auriculata seeds
title Inhibition of melanin production by anthracenone dimer glycosides isolated from Cassia auriculata seeds
title_full Inhibition of melanin production by anthracenone dimer glycosides isolated from Cassia auriculata seeds
title_fullStr Inhibition of melanin production by anthracenone dimer glycosides isolated from Cassia auriculata seeds
title_full_unstemmed Inhibition of melanin production by anthracenone dimer glycosides isolated from Cassia auriculata seeds
title_short Inhibition of melanin production by anthracenone dimer glycosides isolated from Cassia auriculata seeds
title_sort inhibition of melanin production by anthracenone dimer glycosides isolated from cassia auriculata seeds
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176596/
https://www.ncbi.nlm.nih.gov/pubmed/30847755
http://dx.doi.org/10.1007/s11418-018-01276-2
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