Arsenic Trioxide exerts cytotoxic and radiosensitizing effects in pediatric Medulloblastoma cell lines of SHH Subgroup

We evaluated the potential effects of ATO in different pediatric SHH-MB cell lines (ONS-76: TP53-wild type; DAOY and UW402: TP53-mutated). MB cell lines molecular subgroup was confirmed and TP53 mutations were validated. Cell viability, clonogenicity and apoptosis were evaluated after ATO treatment...

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Detalles Bibliográficos
Autores principales: dos Santos Klinger, Paulo Henrique, Delsin, Lara Elis Alberici, Cruzeiro, Gustavo Alencastro Veiga, Andrade, Augusto Faria, Lira, Regia Caroline Peixoto, de Andrade, Pamela Viani, das Chagas, Pablo Ferreira, de Paula Queiroz, Rosane Gomes, Trevisan, Felipe Amstalden, de Oliveira, Ricardo Santos, Scrideli, Carlos Alberto, Tone, Luiz Gonzaga, Valera, Elvis Terci
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176640/
https://www.ncbi.nlm.nih.gov/pubmed/32321992
http://dx.doi.org/10.1038/s41598-020-63808-9

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