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A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells
Although cellular senescence acts primarily as a tumour suppression mechanism, the accumulation of senescent cells in vivo eventually exerts deleterious side effects through inflammatory/tumour-promoting factor secretion. Thus, the development of new drugs that cause the specific elimination of sene...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176673/ https://www.ncbi.nlm.nih.gov/pubmed/32321921 http://dx.doi.org/10.1038/s41467-020-15719-6 |