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Gamma glutamyltransferase and risk of dementia in prediabetes and diabetes
Diabetes is associated with cognitive impairment and greater risk for dementia, but the role of gamma-glutamyltransferase (γ-GT) in dementia has not been elucidated. We determined incident dementia including Alzheimer’s disease and vascular dementia, analyzing data from participants aged 40 years or...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176727/ https://www.ncbi.nlm.nih.gov/pubmed/32322005 http://dx.doi.org/10.1038/s41598-020-63803-0 |
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author | Han, Eugene Lee, Ji-Yeon Han, Kyung-do Cho, Hanna Kim, Kwang Joon Lee, Byung-Wan Kang, Eun Seok Cha, Bong-Soo Younossi, Zobair M Lee, Yong-ho |
author_facet | Han, Eugene Lee, Ji-Yeon Han, Kyung-do Cho, Hanna Kim, Kwang Joon Lee, Byung-Wan Kang, Eun Seok Cha, Bong-Soo Younossi, Zobair M Lee, Yong-ho |
author_sort | Han, Eugene |
collection | PubMed |
description | Diabetes is associated with cognitive impairment and greater risk for dementia, but the role of gamma-glutamyltransferase (γ-GT) in dementia has not been elucidated. We determined incident dementia including Alzheimer’s disease and vascular dementia, analyzing data from participants aged 40 years or older in the National Health Insurance Database, collected by the National Health Insurance Service in Korea, from January 2009 to December 2015. During a median follow-up of 7.6 years, 272,657 participants were diagnosed as having dementia. Higher serum γ-GT was associated with increased risk of dementia (HR = 1.22, 95% CI = 1.20–1.24), and had a strong positive association with early onset dementia (HR = 1.32, 95% CI = 1.24–1.40). An additive impact of higher γ-GT on dementia was observed regardless of glycemic status, and prevalent diabetes with the highest γ-GT quartile had a 1.8-fold increased dementia risk (HR = 1.82, 95% CI = 1.78–1.85). This effect of γ-GT concentration in diabetes was more prominent in individuals with vascular dementia (HR = 1.94, 95% CI = 1.84–2.04). In subgroup analysis, young age, male sex, and relatively healthy subjects with a higher γ-GT quartile had more increased dementia risk. In conclusion, γ-GT concentration as well as glycemic status could be a future risk factor for dementia in the general population. |
format | Online Article Text |
id | pubmed-7176727 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-71767272020-04-27 Gamma glutamyltransferase and risk of dementia in prediabetes and diabetes Han, Eugene Lee, Ji-Yeon Han, Kyung-do Cho, Hanna Kim, Kwang Joon Lee, Byung-Wan Kang, Eun Seok Cha, Bong-Soo Younossi, Zobair M Lee, Yong-ho Sci Rep Article Diabetes is associated with cognitive impairment and greater risk for dementia, but the role of gamma-glutamyltransferase (γ-GT) in dementia has not been elucidated. We determined incident dementia including Alzheimer’s disease and vascular dementia, analyzing data from participants aged 40 years or older in the National Health Insurance Database, collected by the National Health Insurance Service in Korea, from January 2009 to December 2015. During a median follow-up of 7.6 years, 272,657 participants were diagnosed as having dementia. Higher serum γ-GT was associated with increased risk of dementia (HR = 1.22, 95% CI = 1.20–1.24), and had a strong positive association with early onset dementia (HR = 1.32, 95% CI = 1.24–1.40). An additive impact of higher γ-GT on dementia was observed regardless of glycemic status, and prevalent diabetes with the highest γ-GT quartile had a 1.8-fold increased dementia risk (HR = 1.82, 95% CI = 1.78–1.85). This effect of γ-GT concentration in diabetes was more prominent in individuals with vascular dementia (HR = 1.94, 95% CI = 1.84–2.04). In subgroup analysis, young age, male sex, and relatively healthy subjects with a higher γ-GT quartile had more increased dementia risk. In conclusion, γ-GT concentration as well as glycemic status could be a future risk factor for dementia in the general population. Nature Publishing Group UK 2020-04-22 /pmc/articles/PMC7176727/ /pubmed/32322005 http://dx.doi.org/10.1038/s41598-020-63803-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Han, Eugene Lee, Ji-Yeon Han, Kyung-do Cho, Hanna Kim, Kwang Joon Lee, Byung-Wan Kang, Eun Seok Cha, Bong-Soo Younossi, Zobair M Lee, Yong-ho Gamma glutamyltransferase and risk of dementia in prediabetes and diabetes |
title | Gamma glutamyltransferase and risk of dementia in prediabetes and diabetes |
title_full | Gamma glutamyltransferase and risk of dementia in prediabetes and diabetes |
title_fullStr | Gamma glutamyltransferase and risk of dementia in prediabetes and diabetes |
title_full_unstemmed | Gamma glutamyltransferase and risk of dementia in prediabetes and diabetes |
title_short | Gamma glutamyltransferase and risk of dementia in prediabetes and diabetes |
title_sort | gamma glutamyltransferase and risk of dementia in prediabetes and diabetes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176727/ https://www.ncbi.nlm.nih.gov/pubmed/32322005 http://dx.doi.org/10.1038/s41598-020-63803-0 |
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