A New Antimalarial Noreudesmane Sesquiterpenoid from Dobinea delavayi

ABSTRACT: One previously undescribed angeloylated noreudesmane sesquiterpenoid, dobinin O (1), along with four known eudesmane sesquiterpenoids (2–5) were isolated from the peeled roots of Dobinea delavayi. Their structures were elucidated by extensive spectroscopic data analyses. In addition, compo...

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Detalles Bibliográficos
Autores principales: Wu, Xiu-Rong, Shen, Yi, Cui, Shu-Jun, Luo, Xiao-Lei, Xiao, Chao-Jiang, Jiang, Bei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176782/
https://www.ncbi.nlm.nih.gov/pubmed/32096092
http://dx.doi.org/10.1007/s13659-020-00234-4
Descripción
Sumario:ABSTRACT: One previously undescribed angeloylated noreudesmane sesquiterpenoid, dobinin O (1), along with four known eudesmane sesquiterpenoids (2–5) were isolated from the peeled roots of Dobinea delavayi. Their structures were elucidated by extensive spectroscopic data analyses. In addition, compound 1 exhibited moderate antimalarial activity against Plasmodium yoelii BY265RFP with the inhibition ratio of 17.8 ± 13.3% at the dose of 30 mg/kg/day. GRAPHIC ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-020-00234-4) contains supplementary material, which is available to authorized users.

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