A New Antimalarial Noreudesmane Sesquiterpenoid from Dobinea delavayi

ABSTRACT: One previously undescribed angeloylated noreudesmane sesquiterpenoid, dobinin O (1), along with four known eudesmane sesquiterpenoids (2–5) were isolated from the peeled roots of Dobinea delavayi. Their structures were elucidated by extensive spectroscopic data analyses. In addition, compo...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Xiu-Rong, Shen, Yi, Cui, Shu-Jun, Luo, Xiao-Lei, Xiao, Chao-Jiang, Jiang, Bei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176782/
https://www.ncbi.nlm.nih.gov/pubmed/32096092
http://dx.doi.org/10.1007/s13659-020-00234-4
_version_ 1783525073380966400
author Wu, Xiu-Rong
Shen, Yi
Cui, Shu-Jun
Luo, Xiao-Lei
Xiao, Chao-Jiang
Jiang, Bei
author_facet Wu, Xiu-Rong
Shen, Yi
Cui, Shu-Jun
Luo, Xiao-Lei
Xiao, Chao-Jiang
Jiang, Bei
author_sort Wu, Xiu-Rong
collection PubMed
description ABSTRACT: One previously undescribed angeloylated noreudesmane sesquiterpenoid, dobinin O (1), along with four known eudesmane sesquiterpenoids (2–5) were isolated from the peeled roots of Dobinea delavayi. Their structures were elucidated by extensive spectroscopic data analyses. In addition, compound 1 exhibited moderate antimalarial activity against Plasmodium yoelii BY265RFP with the inhibition ratio of 17.8 ± 13.3% at the dose of 30 mg/kg/day. GRAPHIC ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-020-00234-4) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-7176782
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Springer Singapore
record_format MEDLINE/PubMed
spelling pubmed-71767822020-04-28 A New Antimalarial Noreudesmane Sesquiterpenoid from Dobinea delavayi Wu, Xiu-Rong Shen, Yi Cui, Shu-Jun Luo, Xiao-Lei Xiao, Chao-Jiang Jiang, Bei Nat Prod Bioprospect Original Article ABSTRACT: One previously undescribed angeloylated noreudesmane sesquiterpenoid, dobinin O (1), along with four known eudesmane sesquiterpenoids (2–5) were isolated from the peeled roots of Dobinea delavayi. Their structures were elucidated by extensive spectroscopic data analyses. In addition, compound 1 exhibited moderate antimalarial activity against Plasmodium yoelii BY265RFP with the inhibition ratio of 17.8 ± 13.3% at the dose of 30 mg/kg/day. GRAPHIC ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-020-00234-4) contains supplementary material, which is available to authorized users. Springer Singapore 2020-02-24 /pmc/articles/PMC7176782/ /pubmed/32096092 http://dx.doi.org/10.1007/s13659-020-00234-4 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
Wu, Xiu-Rong
Shen, Yi
Cui, Shu-Jun
Luo, Xiao-Lei
Xiao, Chao-Jiang
Jiang, Bei
A New Antimalarial Noreudesmane Sesquiterpenoid from Dobinea delavayi
title A New Antimalarial Noreudesmane Sesquiterpenoid from Dobinea delavayi
title_full A New Antimalarial Noreudesmane Sesquiterpenoid from Dobinea delavayi
title_fullStr A New Antimalarial Noreudesmane Sesquiterpenoid from Dobinea delavayi
title_full_unstemmed A New Antimalarial Noreudesmane Sesquiterpenoid from Dobinea delavayi
title_short A New Antimalarial Noreudesmane Sesquiterpenoid from Dobinea delavayi
title_sort new antimalarial noreudesmane sesquiterpenoid from dobinea delavayi
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176782/
https://www.ncbi.nlm.nih.gov/pubmed/32096092
http://dx.doi.org/10.1007/s13659-020-00234-4
work_keys_str_mv AT wuxiurong anewantimalarialnoreudesmanesesquiterpenoidfromdobineadelavayi
AT shenyi anewantimalarialnoreudesmanesesquiterpenoidfromdobineadelavayi
AT cuishujun anewantimalarialnoreudesmanesesquiterpenoidfromdobineadelavayi
AT luoxiaolei anewantimalarialnoreudesmanesesquiterpenoidfromdobineadelavayi
AT xiaochaojiang anewantimalarialnoreudesmanesesquiterpenoidfromdobineadelavayi
AT jiangbei anewantimalarialnoreudesmanesesquiterpenoidfromdobineadelavayi
AT wuxiurong newantimalarialnoreudesmanesesquiterpenoidfromdobineadelavayi
AT shenyi newantimalarialnoreudesmanesesquiterpenoidfromdobineadelavayi
AT cuishujun newantimalarialnoreudesmanesesquiterpenoidfromdobineadelavayi
AT luoxiaolei newantimalarialnoreudesmanesesquiterpenoidfromdobineadelavayi
AT xiaochaojiang newantimalarialnoreudesmanesesquiterpenoidfromdobineadelavayi
AT jiangbei newantimalarialnoreudesmanesesquiterpenoidfromdobineadelavayi

Ejemplares similares