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LncRNA FTX activates FOXA2 expression to inhibit non–small‐cell lung cancer proliferation and metastasis

Lung cancer leads to the highest mortality among all cancer types in the world, and non–small‐cell lung cancer (NSCLC) occupies over 80% of the lung cancer cases. Numerous studies have demonstrated that long non‐coding RNA (lncRNA) is involved in various human diseases including cancer. LncRNA FTX w...

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Autores principales: Jin, Shidai, He, Jing, Zhou, Yue, Wu, Deqin, Li, Jun, Gao, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176842/
https://www.ncbi.nlm.nih.gov/pubmed/32176463
http://dx.doi.org/10.1111/jcmm.15163
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author Jin, Shidai
He, Jing
Zhou, Yue
Wu, Deqin
Li, Jun
Gao, Wen
author_facet Jin, Shidai
He, Jing
Zhou, Yue
Wu, Deqin
Li, Jun
Gao, Wen
author_sort Jin, Shidai
collection PubMed
description Lung cancer leads to the highest mortality among all cancer types in the world, and non–small‐cell lung cancer (NSCLC) occupies over 80% of the lung cancer cases. Numerous studies have demonstrated that long non‐coding RNA (lncRNA) is involved in various human diseases including cancer. LncRNA FTX was firstly identified in Xist gene locus and was dysregulated in many human cancers. However, the function of FTX in NSCLC is still unclear. Here, we report that long non‐coding RNA FTX expression level is down‐regulated in NSCLC clinical tissue samples and cell lines. Ectopic expression of FTX inhibits proliferation and metastasis of lung cancer cells in vitro and in vivo. Furthermore, we find that FTX overexpression activates the expression of transcription factor FOXA2, an important regulator in lung cancer progression, and we reveal a novel FTX/miR‐200a‐3p/FOXA2 competing endogenous RNA regulatory axis in lung cancer cells. Our results provide new insights and directions for exploring the function of FTX in lung cancer progression.
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spelling pubmed-71768422020-04-24 LncRNA FTX activates FOXA2 expression to inhibit non–small‐cell lung cancer proliferation and metastasis Jin, Shidai He, Jing Zhou, Yue Wu, Deqin Li, Jun Gao, Wen J Cell Mol Med Original Articles Lung cancer leads to the highest mortality among all cancer types in the world, and non–small‐cell lung cancer (NSCLC) occupies over 80% of the lung cancer cases. Numerous studies have demonstrated that long non‐coding RNA (lncRNA) is involved in various human diseases including cancer. LncRNA FTX was firstly identified in Xist gene locus and was dysregulated in many human cancers. However, the function of FTX in NSCLC is still unclear. Here, we report that long non‐coding RNA FTX expression level is down‐regulated in NSCLC clinical tissue samples and cell lines. Ectopic expression of FTX inhibits proliferation and metastasis of lung cancer cells in vitro and in vivo. Furthermore, we find that FTX overexpression activates the expression of transcription factor FOXA2, an important regulator in lung cancer progression, and we reveal a novel FTX/miR‐200a‐3p/FOXA2 competing endogenous RNA regulatory axis in lung cancer cells. Our results provide new insights and directions for exploring the function of FTX in lung cancer progression. John Wiley and Sons Inc. 2020-03-16 2020-04 /pmc/articles/PMC7176842/ /pubmed/32176463 http://dx.doi.org/10.1111/jcmm.15163 Text en © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Jin, Shidai
He, Jing
Zhou, Yue
Wu, Deqin
Li, Jun
Gao, Wen
LncRNA FTX activates FOXA2 expression to inhibit non–small‐cell lung cancer proliferation and metastasis
title LncRNA FTX activates FOXA2 expression to inhibit non–small‐cell lung cancer proliferation and metastasis
title_full LncRNA FTX activates FOXA2 expression to inhibit non–small‐cell lung cancer proliferation and metastasis
title_fullStr LncRNA FTX activates FOXA2 expression to inhibit non–small‐cell lung cancer proliferation and metastasis
title_full_unstemmed LncRNA FTX activates FOXA2 expression to inhibit non–small‐cell lung cancer proliferation and metastasis
title_short LncRNA FTX activates FOXA2 expression to inhibit non–small‐cell lung cancer proliferation and metastasis
title_sort lncrna ftx activates foxa2 expression to inhibit non–small‐cell lung cancer proliferation and metastasis
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176842/
https://www.ncbi.nlm.nih.gov/pubmed/32176463
http://dx.doi.org/10.1111/jcmm.15163
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