IRF-7 Mediates Type I IFN Responses in Endotoxin-Challenged Mice

IRF-7 mediates robust production of type I IFN via MyD88 of the TLR9 pathway in plasmacytoid dendritic cells (pDCs). Previous in vitro studies using bone marrow-derived dendritic cells lacking either Irf7 or Irf3 have demonstrated that only IRF-3 is required for IFN-β production in the TLR4 pathway....

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Detalles Bibliográficos
Autores principales: Sin, Wei-Xiang, Yeong, Joe Poh-Sheng, Lim, Thomas Jun Feng, Su, I-Hsin, Connolly, John E., Chin, Keh-Chuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176903/
https://www.ncbi.nlm.nih.gov/pubmed/32373120
http://dx.doi.org/10.3389/fimmu.2020.00640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176903/
https://www.ncbi.nlm.nih.gov/pubmed/32373120
http://dx.doi.org/10.3389/fimmu.2020.00640

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