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Clinical and epidemiological features of COVID-19 family clusters in Beijing, China

BACKGROUND: Since its discovery, SARS-CoV-2 has been spread throughout China before becoming a global pandemic. In Beijing, family clusters are the main mode of human-human transmission accounting for 57.6% of the total confirmed cases. METHOD: We present the epidemiological and clinical features of...

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Autores principales: Song, Rui, Han, Bing, Song, Meihua, Wang, Lin, Conlon, Christopher P., Dong, Tao, Tian, Di, Zhang, Wei, Chen, Zhihai, Zhang, Fujie, Shi, Mang, Li, Xingwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The British Infection Association. Published by Elsevier Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177072/
https://www.ncbi.nlm.nih.gov/pubmed/32335171
http://dx.doi.org/10.1016/j.jinf.2020.04.018
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author Song, Rui
Han, Bing
Song, Meihua
Wang, Lin
Conlon, Christopher P.
Dong, Tao
Tian, Di
Zhang, Wei
Chen, Zhihai
Zhang, Fujie
Shi, Mang
Li, Xingwang
author_facet Song, Rui
Han, Bing
Song, Meihua
Wang, Lin
Conlon, Christopher P.
Dong, Tao
Tian, Di
Zhang, Wei
Chen, Zhihai
Zhang, Fujie
Shi, Mang
Li, Xingwang
author_sort Song, Rui
collection PubMed
description BACKGROUND: Since its discovery, SARS-CoV-2 has been spread throughout China before becoming a global pandemic. In Beijing, family clusters are the main mode of human-human transmission accounting for 57.6% of the total confirmed cases. METHOD: We present the epidemiological and clinical features of the clusters of three large and one small families. RESULT: Our results revealed that SARS-CoV-2 is transmitted quickly through contact with index case, and a total of 22/24 infections were observed. Among those infected, 20/22 had mild symptoms and only two had moderate to severe clinical manifestations. Children in the families generally showed milder symptoms. The incubation period varied from 2 to 13 days, and the shedding of virus from the upper respiratory tract lasted from 5 to over 30 days. A prolonged period of virus shedding (>30 days) in upper respiratory tract was observed in 6/24 cases. CONCLUSION: SARS-CoV-2 is transmitted quickly in the form of family clusters. While the infection rate is high within the cluster, the disease manifestations, latent period, and virus shedding period varied greatly. We therefore recommend rigorously testing contacts even during the no-symptom phase and consider whether viral shedding has ceased before stopping isolation measures for an individual.
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spelling pubmed-71770722020-04-23 Clinical and epidemiological features of COVID-19 family clusters in Beijing, China Song, Rui Han, Bing Song, Meihua Wang, Lin Conlon, Christopher P. Dong, Tao Tian, Di Zhang, Wei Chen, Zhihai Zhang, Fujie Shi, Mang Li, Xingwang J Infect Article BACKGROUND: Since its discovery, SARS-CoV-2 has been spread throughout China before becoming a global pandemic. In Beijing, family clusters are the main mode of human-human transmission accounting for 57.6% of the total confirmed cases. METHOD: We present the epidemiological and clinical features of the clusters of three large and one small families. RESULT: Our results revealed that SARS-CoV-2 is transmitted quickly through contact with index case, and a total of 22/24 infections were observed. Among those infected, 20/22 had mild symptoms and only two had moderate to severe clinical manifestations. Children in the families generally showed milder symptoms. The incubation period varied from 2 to 13 days, and the shedding of virus from the upper respiratory tract lasted from 5 to over 30 days. A prolonged period of virus shedding (>30 days) in upper respiratory tract was observed in 6/24 cases. CONCLUSION: SARS-CoV-2 is transmitted quickly in the form of family clusters. While the infection rate is high within the cluster, the disease manifestations, latent period, and virus shedding period varied greatly. We therefore recommend rigorously testing contacts even during the no-symptom phase and consider whether viral shedding has ceased before stopping isolation measures for an individual. The British Infection Association. Published by Elsevier Ltd. 2020-08 2020-04-23 /pmc/articles/PMC7177072/ /pubmed/32335171 http://dx.doi.org/10.1016/j.jinf.2020.04.018 Text en © 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Song, Rui
Han, Bing
Song, Meihua
Wang, Lin
Conlon, Christopher P.
Dong, Tao
Tian, Di
Zhang, Wei
Chen, Zhihai
Zhang, Fujie
Shi, Mang
Li, Xingwang
Clinical and epidemiological features of COVID-19 family clusters in Beijing, China
title Clinical and epidemiological features of COVID-19 family clusters in Beijing, China
title_full Clinical and epidemiological features of COVID-19 family clusters in Beijing, China
title_fullStr Clinical and epidemiological features of COVID-19 family clusters in Beijing, China
title_full_unstemmed Clinical and epidemiological features of COVID-19 family clusters in Beijing, China
title_short Clinical and epidemiological features of COVID-19 family clusters in Beijing, China
title_sort clinical and epidemiological features of covid-19 family clusters in beijing, china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177072/
https://www.ncbi.nlm.nih.gov/pubmed/32335171
http://dx.doi.org/10.1016/j.jinf.2020.04.018
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