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The protective and pathogenic roles of CXCL17 in human health and disease: Potential in respiratory medicine

C-X-C motif chemokine 17 (CXCL-17) is a novel chemokine that plays a functional role maintaining homeostasis at distinct mucosal barriers, including regulation of myeloid-cell recruitment, angiogenesis, and control of microorganisms. Particularly, CXCL17 is produced along the epithelium of the airwa...

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Autores principales: Choreño-Parra, José Alberto, Thirunavukkarasu, Shyamala, Zúñiga, Joaquín, Khader, Shabaana A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177079/
https://www.ncbi.nlm.nih.gov/pubmed/32345516
http://dx.doi.org/10.1016/j.cytogfr.2020.04.004
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author Choreño-Parra, José Alberto
Thirunavukkarasu, Shyamala
Zúñiga, Joaquín
Khader, Shabaana A.
author_facet Choreño-Parra, José Alberto
Thirunavukkarasu, Shyamala
Zúñiga, Joaquín
Khader, Shabaana A.
author_sort Choreño-Parra, José Alberto
collection PubMed
description C-X-C motif chemokine 17 (CXCL-17) is a novel chemokine that plays a functional role maintaining homeostasis at distinct mucosal barriers, including regulation of myeloid-cell recruitment, angiogenesis, and control of microorganisms. Particularly, CXCL17 is produced along the epithelium of the airways both at steady state and under inflammatory conditions. While increased CXCL17 expression is associated with disease progression in pulmonary fibrosis, asthma, and lung/hepatic cancer, it is thought to play a protective role in pancreatic cancer, autoimmune encephalomyelitis and viral infections. Thus, there is emerging evidence pointing to both a harmful and protective role for CXCL17 in human health and disease, with therapeutic potential for translational applications. In this review, we provide an overview of the discovery, characteristics and functions of CXCL17 emphasizing its clinical potential in respiratory disorders.
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spelling pubmed-71770792020-04-23 The protective and pathogenic roles of CXCL17 in human health and disease: Potential in respiratory medicine Choreño-Parra, José Alberto Thirunavukkarasu, Shyamala Zúñiga, Joaquín Khader, Shabaana A. Cytokine Growth Factor Rev Article C-X-C motif chemokine 17 (CXCL-17) is a novel chemokine that plays a functional role maintaining homeostasis at distinct mucosal barriers, including regulation of myeloid-cell recruitment, angiogenesis, and control of microorganisms. Particularly, CXCL17 is produced along the epithelium of the airways both at steady state and under inflammatory conditions. While increased CXCL17 expression is associated with disease progression in pulmonary fibrosis, asthma, and lung/hepatic cancer, it is thought to play a protective role in pancreatic cancer, autoimmune encephalomyelitis and viral infections. Thus, there is emerging evidence pointing to both a harmful and protective role for CXCL17 in human health and disease, with therapeutic potential for translational applications. In this review, we provide an overview of the discovery, characteristics and functions of CXCL17 emphasizing its clinical potential in respiratory disorders. Elsevier Ltd. 2020-06 2020-04-23 /pmc/articles/PMC7177079/ /pubmed/32345516 http://dx.doi.org/10.1016/j.cytogfr.2020.04.004 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Choreño-Parra, José Alberto
Thirunavukkarasu, Shyamala
Zúñiga, Joaquín
Khader, Shabaana A.
The protective and pathogenic roles of CXCL17 in human health and disease: Potential in respiratory medicine
title The protective and pathogenic roles of CXCL17 in human health and disease: Potential in respiratory medicine
title_full The protective and pathogenic roles of CXCL17 in human health and disease: Potential in respiratory medicine
title_fullStr The protective and pathogenic roles of CXCL17 in human health and disease: Potential in respiratory medicine
title_full_unstemmed The protective and pathogenic roles of CXCL17 in human health and disease: Potential in respiratory medicine
title_short The protective and pathogenic roles of CXCL17 in human health and disease: Potential in respiratory medicine
title_sort protective and pathogenic roles of cxcl17 in human health and disease: potential in respiratory medicine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177079/
https://www.ncbi.nlm.nih.gov/pubmed/32345516
http://dx.doi.org/10.1016/j.cytogfr.2020.04.004
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