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Disturbance of Oxidative Stress Parameters in Treatment-Resistant Bipolar Disorder and Their Association With Electroconvulsive Therapy Response

OBJECTIVE: Electroconvulsive therapy (ECT) is an effective option for treatment-resistant bipolar disorder (trBD). However, the mechanisms of its effect are unknown. Oxidative stress is thought to be involved in the underpinnings of BD. Our study is the first, to our knowledge, to report the associa...

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Autores principales: Lv, Qinyu, Hu, Qiongyue, Zhang, Wenzhong, Huang, Xinxin, Zhu, Minghuan, Geng, Ruijie, Cheng, Xiaoyan, Bao, Chenxi, Wang, Yingyi, Zhang, Chen, He, Yongguang, Li, Zezhi, Yi, Zhenghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177162/
https://www.ncbi.nlm.nih.gov/pubmed/31967315
http://dx.doi.org/10.1093/ijnp/pyaa003
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author Lv, Qinyu
Hu, Qiongyue
Zhang, Wenzhong
Huang, Xinxin
Zhu, Minghuan
Geng, Ruijie
Cheng, Xiaoyan
Bao, Chenxi
Wang, Yingyi
Zhang, Chen
He, Yongguang
Li, Zezhi
Yi, Zhenghui
author_facet Lv, Qinyu
Hu, Qiongyue
Zhang, Wenzhong
Huang, Xinxin
Zhu, Minghuan
Geng, Ruijie
Cheng, Xiaoyan
Bao, Chenxi
Wang, Yingyi
Zhang, Chen
He, Yongguang
Li, Zezhi
Yi, Zhenghui
author_sort Lv, Qinyu
collection PubMed
description OBJECTIVE: Electroconvulsive therapy (ECT) is an effective option for treatment-resistant bipolar disorder (trBD). However, the mechanisms of its effect are unknown. Oxidative stress is thought to be involved in the underpinnings of BD. Our study is the first, to our knowledge, to report the association between notable oxidative stress parameters (superoxide dismutase [SOD], glutathione peroxidase [GSH-Px], catalase [CAT], and malondialdehyde [MDA]) levels and ECT response in trBD patients. METHODS: A total 28 trBD patients and 49 controls were recruited. Six-week ECT and naturalistic follow-up were conducted. SOD, GSH-Px, CAT, and MDA levels were measured by enzyme-linked immunosorbent assay, and the 17-item Hamilton Depression Rating Scale and Young Mania Rating Scale were administered at baseline and the end of the 6th week. MANCOVA, ANCOVA, 2 × 2 ANCOVA, and a multiple regression model were conducted. RESULTS: SOD levels were lower in both trBD mania and depression (P = .001; P = .001), while GSH-Px (P = .01; P = .001) and MDA (P = .001; P = .001) were higher in both trBD mania and depression compared with controls. CAT levels were positively associated with 17-item Hamilton Depression Rating Scale scores in trBD depression (r(adjusted)  = 0.83, P = .005). MDA levels in trBD decreased after 6 weeks of ECT (P = .001). Interestingly, MDA levels decreased in responders (P = .001) but not in nonresponders (P > .05). CONCLUSIONS: Our study indicates that decreased SOD could be a trait rather than a state in trBD. Oxidative stress levels are associated with illness severity and ECT response. This suggests that the mechanism of oxidative stress plays a crucial role in the pathophysiology of trBD.
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spelling pubmed-71771622020-04-28 Disturbance of Oxidative Stress Parameters in Treatment-Resistant Bipolar Disorder and Their Association With Electroconvulsive Therapy Response Lv, Qinyu Hu, Qiongyue Zhang, Wenzhong Huang, Xinxin Zhu, Minghuan Geng, Ruijie Cheng, Xiaoyan Bao, Chenxi Wang, Yingyi Zhang, Chen He, Yongguang Li, Zezhi Yi, Zhenghui Int J Neuropsychopharmacol Regular Research Articles OBJECTIVE: Electroconvulsive therapy (ECT) is an effective option for treatment-resistant bipolar disorder (trBD). However, the mechanisms of its effect are unknown. Oxidative stress is thought to be involved in the underpinnings of BD. Our study is the first, to our knowledge, to report the association between notable oxidative stress parameters (superoxide dismutase [SOD], glutathione peroxidase [GSH-Px], catalase [CAT], and malondialdehyde [MDA]) levels and ECT response in trBD patients. METHODS: A total 28 trBD patients and 49 controls were recruited. Six-week ECT and naturalistic follow-up were conducted. SOD, GSH-Px, CAT, and MDA levels were measured by enzyme-linked immunosorbent assay, and the 17-item Hamilton Depression Rating Scale and Young Mania Rating Scale were administered at baseline and the end of the 6th week. MANCOVA, ANCOVA, 2 × 2 ANCOVA, and a multiple regression model were conducted. RESULTS: SOD levels were lower in both trBD mania and depression (P = .001; P = .001), while GSH-Px (P = .01; P = .001) and MDA (P = .001; P = .001) were higher in both trBD mania and depression compared with controls. CAT levels were positively associated with 17-item Hamilton Depression Rating Scale scores in trBD depression (r(adjusted)  = 0.83, P = .005). MDA levels in trBD decreased after 6 weeks of ECT (P = .001). Interestingly, MDA levels decreased in responders (P = .001) but not in nonresponders (P > .05). CONCLUSIONS: Our study indicates that decreased SOD could be a trait rather than a state in trBD. Oxidative stress levels are associated with illness severity and ECT response. This suggests that the mechanism of oxidative stress plays a crucial role in the pathophysiology of trBD. Oxford University Press 2020-01-22 /pmc/articles/PMC7177162/ /pubmed/31967315 http://dx.doi.org/10.1093/ijnp/pyaa003 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of CINP. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Regular Research Articles
Lv, Qinyu
Hu, Qiongyue
Zhang, Wenzhong
Huang, Xinxin
Zhu, Minghuan
Geng, Ruijie
Cheng, Xiaoyan
Bao, Chenxi
Wang, Yingyi
Zhang, Chen
He, Yongguang
Li, Zezhi
Yi, Zhenghui
Disturbance of Oxidative Stress Parameters in Treatment-Resistant Bipolar Disorder and Their Association With Electroconvulsive Therapy Response
title Disturbance of Oxidative Stress Parameters in Treatment-Resistant Bipolar Disorder and Their Association With Electroconvulsive Therapy Response
title_full Disturbance of Oxidative Stress Parameters in Treatment-Resistant Bipolar Disorder and Their Association With Electroconvulsive Therapy Response
title_fullStr Disturbance of Oxidative Stress Parameters in Treatment-Resistant Bipolar Disorder and Their Association With Electroconvulsive Therapy Response
title_full_unstemmed Disturbance of Oxidative Stress Parameters in Treatment-Resistant Bipolar Disorder and Their Association With Electroconvulsive Therapy Response
title_short Disturbance of Oxidative Stress Parameters in Treatment-Resistant Bipolar Disorder and Their Association With Electroconvulsive Therapy Response
title_sort disturbance of oxidative stress parameters in treatment-resistant bipolar disorder and their association with electroconvulsive therapy response
topic Regular Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177162/
https://www.ncbi.nlm.nih.gov/pubmed/31967315
http://dx.doi.org/10.1093/ijnp/pyaa003
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