Cargando…

Effects of an Aquaporin 4 Inhibitor, TGN-020, on Murine Diabetic Retina

Purpose: To investigate the effect of a selective aquaporin 4 (AQP4) inhibitor, 2-(nicotinamide)-1,3,4-thiadiazole (TGN-020), on the expression of vascular endothelial growth factor (VEGF) and reactive oxygen species (ROS) production, as well as on the retinal edema in diabetic retina. Methods: Intr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oosuka, Shou, Kida, Teruyo, Oku, Hidehiro, Horie, Taeko, Morishita, Seita, Fukumoto, Masanori, Sato, Takaki, Ikeda, Tsunehiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177210/ https://www.ncbi.nlm.nih.gov/pubmed/32230876 http://dx.doi.org/10.3390/ijms21072324

Ejemplares similares

Changes in Expression of Aquaporin-4 and Aquaporin-9 in Optic Nerve after Crushing in Rats
por: Suzuki, Hiroyuki, et al.
Publicado: (2014)

Expression of Lymphatic Markers in the Berger’s Space and Bursa Premacularis
por: Morishita, Seita, et al.
Publicado: (2021)

Clinical Features of Vitreomacular Traction Syndrome with Peripheral Vitreoretinal Adhesion
por: Fukumoto, Masanori, et al.
Publicado: (2020)

Long-term evaluation of spontaneous release of epiretinal membrane and its possible pathogenesis
por: Kida, Teruyo, et al.
Publicado: (2017)

Involvement of premacular mast cells in the pathogenesis of macular diseases
por: Sato, Takaki, et al.
Publicado: (2019)

A comparison of sex steroid concentration levels in the vitreous and serum of patients with vitreoretinal diseases
por: Nishikawa, Yuko, et al.
Publicado: (2017)

Immunohistological Study of Monkey Foveal Retina
por: Ikeda, Tsunehiko, et al.
Publicado: (2019)

Data on the involvement of endothelin-1 (ET-1) in the dysregulation of retinal veins
por: Kida, Teruyo, et al.
Publicado: (2018)

The role of tryptase and anti-type II collagen antibodies in the pathogenesis of idiopathic epiretinal membranes
por: Ikeda, Tsunehiko, et al.
Publicado: (2015)

Spontaneous Closure of the Macular Hole in a Patient with Acquired Vitelliform Lesion
por: Fukumoto, Masanori, et al.
Publicado: (2020)

Vitreous estrogen levels in patients with an idiopathic macular hole
por: Inokuchi, Naoki, et al.
Publicado: (2015)

Measurement of serum and vitreous concentrations of anti-type II collagen antibody in diabetic retinopathy
por: Nakaizumi, Atsuko, et al.
Publicado: (2015)

Suppressed endothelin-1 by anti-VEGF therapy is important for patients with BRVO-related macular edema to improve their vision
por: Kida, Teruyo, et al.
Publicado: (2016)

Bilateral rhegmatogenous retinal detachment due to unusual retinal degeneration in Down syndrome: A case report
por: Yonemoto, Yumiko, et al.
Publicado: (2018)

The effect of vitreomacular adhesion in exudative age-related macular degeneration on the results of ranibizumab intravitreal injection
por: Suzuki, Hiroyuki, et al.
Publicado: (2017)

Hyperglycemia-induced VEGF and ROS production in retinal cells is inhibited by the mTOR inhibitor, rapamycin
por: Kida, Teruyo, et al.
Publicado: (2021)

Involvement of the Retinal Pigment Epithelium in the Development of Retinal Lattice Degeneration
por: Mizuno, Hiroshi, et al.
Publicado: (2020)

Scleral patch grafting for scleral wound thinning after pars plana phacoemulsification and aspiration: A case report
por: Terubayashi, Yuya, et al.
Publicado: (2019)

Valsalva retinopathy induced by handstand: a case report
por: Miyaki, Toshiya, et al.
Publicado: (2020)

Systemic Simvastatin Rescues Retinal Ganglion Cells from Optic Nerve Injury Possibly through Suppression of Astroglial NF-κB Activation
por: Morishita, Seita, et al.
Publicado: (2014)

Development of macular retinoschisis long after the onset of retinal arterial occlusion (RAO): a retrospective study
por: Ishizaki, Norihiko, et al.
Publicado: (2018)

Central Retinal Vein Occlusion in 2 Patients Using Antipsychotic Drugs
por: Taki, Koichiro, et al.
Publicado: (2017)

Two Cases of Proliferative Diabetic Retinopathy with Marked Sheathing of the Retinal Arteries following Vitrectomy
por: Nishikawa, Yuko, et al.
Publicado: (2017)

Treatment of systemic hypertension is important for improvement of macular edema associated with retinal vein occlusion
por: Kida, Teruyo, et al.
Publicado: (2014)

Rhegmatogenous retinal detachment with a giant tear located in the intermediate periphery: Two case reports
por: Kohmoto, Ryohsuke, et al.
Publicado: (2019)

Ciliary body suturing using intraocular irrigation for traumatic cyclodialysis: two case reports
por: Nagashima, Taishi, et al.
Publicado: (2020)

Two cases of diabetic macular edema complicated by an atypical macular hole
por: Yoshida, Yuich, et al.
Publicado: (2020)

Impairment of Autophagy Causes Superoxide Formation and Caspase Activation in 661 W Cells, a Cell Line for Cone Photoreceptors, under Hyperglycemic Conditions
por: Taki, Koichiro, et al.
Publicado: (2020)

A Case of a Vitreomacular Traction-Associated Macular Microhole in an Eye with Focal Choroidal Excavation
por: Fukumoto, Masanori, et al.
Publicado: (2015)

Idiopathic macular hole with asteroid hyalosis: Two case reports
por: Kitagaki, Takakuni, et al.
Publicado: (2018)

Familial exudative vitreoretinopathy complicated with full thickness macular hole: A case report
por: Kimura, Daisaku, et al.
Publicado: (2018)

Case Report of a Family Affected by Stickler Syndrome in Which Rhegmatogenous Retinal Detachment Occurred in Five Eyes of Three Siblings
por: Kimura, Daisaku, et al.
Publicado: (2018)

Long-Term Follow-Up Case of Multiple Retinal Arterial Macroaneurysms Developing Branch Retinal Vein Occlusion following Ruptured Macroaneurysm
por: Terubayashi, Yuya, et al.
Publicado: (2016)

Intravitreal luxated lens stuck on the optic disc: a case report
por: Morishita, Seita, et al.
Publicado: (2016)

Type III uveal effusion syndrome suspected to be related to pachychoroid spectrum disease: A case report
por: Terubayashi, Yuya, et al.
Publicado: (2020)

Involvement of Anoikis in Dissociated Optic Nerve Fiber Layer Appearance
por: Ikeda, Tsunehiko, et al.
Publicado: (2021)

Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema
por: Igarashi, Hironaka, et al.
Publicado: (2010)

A Case of Intraocular Erosion and Intrusion by an Arruga Suture
por: Kitagaki, Takakuni, et al.
Publicado: (2016)

Two Cases of Rhegmatogenous Retinal Detachment Associated with Asteroid Hyalosis
por: Okuda, Yoshitaka, et al.
Publicado: (2018)

Case of asteroid hyalosis that developed severely reduced vision after cataract surgery
por: Ochi, Ryosuke, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_i6lqsb3q8kb7vl7ak9c397ltqp