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Conformational Characterization of Native and L17A/F19A-Substituted Dutch-Type β-Amyloid Peptides

Some mutations which occur in the α/β-discordant region (resides 15 to 23) of β-amyloid peptide (Aβ) lead to familial Alzheimer’s disease (FAD). In vitro studies have shown that these genetic mutations could accelerate Aβ aggregation. We recently showed that mutations in this region could alter the...

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Detalles Bibliográficos
Autores principales:	He, Kai-Cyuan, Chen, Yi-Ru, Liang, Chu-Ting, Huang, Shi-Jie, Tzeng, Chung-Ying, Chang, Chi-Fon, Huang, Shing-Jong, Huang, Hsien-Bin, Lin, Ta-Hsien
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177254/ https://www.ncbi.nlm.nih.gov/pubmed/32272787 http://dx.doi.org/10.3390/ijms21072571

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