Inhibitory Effective Perturbations of Cilobradine (DK-AH269), A Blocker of HCN Channels, on the Amplitude and Gating of Both Hyperpolarization-Activated Cation and Delayed-Rectifier Potassium Currents

Cilobradine (CIL, DK-AH269), an inhibitor of hyperpolarization-activated cation current (I(h)), has been observed to possess pro-arrhythmic properties. Whether and how CIL is capable of perturbing different types of membrane ionic currents existing in electrically excitable cells, however, is incomp...

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Detalles Bibliográficos
Autores principales: Lu, Te-Ling, Lu, Te-Jung, Wu, Sheng-Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177279/
https://www.ncbi.nlm.nih.gov/pubmed/32244431
http://dx.doi.org/10.3390/ijms21072416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177279/
https://www.ncbi.nlm.nih.gov/pubmed/32244431
http://dx.doi.org/10.3390/ijms21072416

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