Pharmacological Inhibition and Activation of the Ca(2+) Activated Cl(−) Channel TMEM16A

TMEM16A is a Ca(2+) activated Cl(−) channel with important functions in airways, intestine, and other epithelial organs. Activation of TMEM16A is proposed as a therapy in cystic fibrosis (CF) to reinstall airway Cl(−) secretion and to enhance airway surface liquid (ASL). This CFTR-agnostic approach...

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Detalles Bibliográficos
Autores principales: Centeio, Raquel, Cabrita, Inês, Benedetto, Roberta, Talbi, Khaoula, Ousingsawat, Jiraporn, Schreiber, Rainer, Sullivan, John K., Kunzelmann, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177308/
https://www.ncbi.nlm.nih.gov/pubmed/32272686
http://dx.doi.org/10.3390/ijms21072557

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177308/
https://www.ncbi.nlm.nih.gov/pubmed/32272686
http://dx.doi.org/10.3390/ijms21072557

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